Functionalized carbon nanomaterials as nanocarriers for loading and delivery of a poorly water-soluble anticancer drug: a comparative study

被引：272

作者：

Sahoo, Nanda Gopal ^{[1
]}

Bao, Hongqian ^{[1
]}

Pan, Yongzheng ^{[1
]}

Pal, Mintu ^{[1
]}

Kakran, Mitali ^{[1
]}

Cheng, Henry Kuo Feng ^{[1
]}

Li, Lin ^{[1
]}

Tan, Lay Poh ^{[2
]}

机构：

[1] Nanyang Technol Univ, Sch Mech & Aerosp Engn, Singapore 639798, Singapore

[2] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 18期

关键词：

TARGETED DELIVERY; MAMMALIAN-CELLS; GRAPHENE OXIDE; NANOTUBES; TRANSPORTERS; COMPOSITE; TOXICITY; DNA;

D O I：

10.1039/c1cc00075f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carbon nanomaterials such as multiwalled carbon nanotubes (MWCNTs) and graphene oxide (GO) have been functionalized by highly hydrophilic and biocompatible poly(vinyl alcohol) (PVA) for loading and delivery of an anticancer drug, camptothecin (CPT). For the first time, CPT was loaded onto MWCNT-PVA and GO-PVA through pi-pi interactions and its capability to kill human breast and skin cancer cells was investigated.

引用

页码：5235 / 5237

页数：3

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