Decreased incidence of febrile episodes with antibiotic prophylaxis in the treatment of decitabine for myelodysplastic syndrome

被引：28

作者：

Lee, Je-Hwan ^{[1
]}

Lee, Kyoo-Hyung ^{[1
]}

Lee, Jung-Hee ^{[1
]}

Kim, Dae-Young ^{[1
]}

Kim, Sung-Han

Lim, Sung-Nam ^{[1
]}

Kim, Sung-Doo ^{[1
]}

Choi, Yunsuk ^{[1
]}

Lee, Sang-Min ^{[2
]}

Lee, Won-Sik ^{[2
]}

Choi, Moon-Young ^{[2
]}

Joo, Young-Don ^{[3
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Hematol, Seoul 138736, South Korea

[2] Inje Univ, Coll Med, Busan Paik Hosp, Dept Internal Med, Pusan, South Korea

[3] Inje Univ, Coll Med, Haeundae Paik Hosp, Dept Hematol, Pusan, South Korea

来源：

LEUKEMIA RESEARCH | 2011年 / 35卷 / 04期

关键词：

Myelodysplastic syndrome; Decitabine; Antibiotic prophylaxis; Febrile episode; Cytopenia; PROGNOSTIC SCORING SYSTEMS; NEUTROPENIC PATIENTS; CANCER-PATIENTS; FLUOROQUINOLONE PROPHYLAXIS; ANTIBACTERIAL PROPHYLAXIS; TARGETED THERAPY; DNA METHYLATION; ACUTE-LEUKEMIA; METAANALYSIS; 5-AZA-2'-DEOXYCYTIDINE;

D O I：

10.1016/j.leukres.2010.07.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We analyzed the role of antibiotic prophylaxis during decitabine treatment for MDS. The primary endpoint was the incidence of febrile episodes. The total number of decitabine cycles given to 28 patients was 131, and febrile episodes occurred in 15 cycles (11.5%). Antibiotic prophylaxis was orally administered in 95 cycles (72.5%). Febrile episodes were significantly less frequent among patients who received antibiotic prophylaxis (7.4%) than in those without prophylaxis (22.2%) (P = 0.017). In conclusion, antibiotic prophylaxis reduced the incidence of febrile episodes in patients who received decitabine treatment for MDS, especially at earlier cycles and in the presence of severe cytopenia. (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：499 / 503

页数：5

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