First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents

被引：25

作者：

Lee, Chia-Lin ^{[1
,8
]}

Huang, Chi-Huan ^{[1
]}

Wang, Hui-Chun ^{[1
]}

Chuang, Da-Wei ^{[1
]}

Wu, Ming-Jung ^{[2
]}

Wang, Sheng-Yang ^{[3
]}

Hwang, Tsong-Long ^{[4
]}

Wu, Chin-Chung ^{[1
]}

Chen, Yeh-Long ^{[5
]}

Chang, Fang-Rong ^{[1
,6
]}

Wu, Yang-Chang ^{[1
,7
,8
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Natl Sun Yant Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

[3] Natl Chung Hsing Univ, Dept Forestry, Taichung 402, Taiwan

[4] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[5] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 807, Taiwan

[6] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan

[7] China Med Univ, Coll Chinese Med, Grad Inst Integrated Med, Taichung 40402, Taiwan

[8] China Med Univ Hosp, Nat Med Prod Res Ctr, Taichung 40402, Taiwan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 01期

关键词：

ANTRODIA-CAMPHORATA; CELLS;

D O I：

10.1039/c0ob00616e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total synthesis of antrocamphin A (1) and its analogs. Their inhibition ability on NO release, superoxide anion generation, elastase release and platelet aggregation are reported herein.

引用

页码：70 / 73

页数：4

共 7 条

[1] Anti-inflammatory benzenoids from Antrodia camphorata [J].