Construction of Acyclic Vicinal Tertiary and Quaternary Carbon Stereocenters via a Pd-Catalyzed Allylic Alkylation of Stereodefined Polysubstituted Ketene Aminals

被引：7

作者：

Huang, Jianqiang ^{[1
]}

Marek, Ilan ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Schulich Fac Chem, IL-3200009 Haifa, Israel

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 21期

基金：

以色列科学基金会;

关键词：

Stereodivergency; Allylation; Quaternary carbon center; Tertiary carbon center; Acyclic systems; HIGHLY STEREOSELECTIVE-SYNTHESIS; IRELAND-CLAISEN REARRANGEMENT; C-H FUNCTIONALIZATION; ADJACENT QUATERNARY; ENANTIOSELECTIVE CONSTRUCTION; STEREOGENIC CENTERS; ALPHA; BETA-UNSATURATED KETONES; CARBOMETALLATION REACTIONS; 1,3-DICARBONYL COMPOUNDS; ASYMMETRIC CONSTRUCTION;

D O I：

10.1002/ejoc.201901741

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Pd/Segphos-catalyzed allylations of stereodefined polysubstituted ketene aminals provide an easy and straightforward access to vicinal acyclic tertiary and quaternary carbon stereocenters with very high diastereo- and enantioselectivity. All possible stereoisomers could be achieved through this diastereodivergent approach.

引用

页码：3133 / 3137

页数：5

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