A New Antibacterial Chlorinated Amino Acid Derivative from the Sponge-Derived Fungus Aspergillus sp. LS53

被引：7

作者：

Zhang, Lu ^{[1
]}

Qiu, Panpan ^{[1
]}

Ding, Lijian ^{[1
]}

Li, Qiang ^{[1
]}

Song, Jingjing ^{[1
]}

Han, Zhiwen ^{[1
]}

He, Shan ^{[1
]}

机构：

[1] Ningbo Univ, Li Dak Sum Yip Yio Chin Kenneth Li Marine Biophar, Ningbo 315800, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2020年 / 56卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Aspergillus sp; 3-chloro-4-hydroxyphenyl unit; sponge-derived fungi; antibacterial activity; METABOLITES;

D O I：

10.1007/s10600-020-02955-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new chlorinated amino acid derivative with a rare 3-chloro-4-hydroxyphenyl unit named aspergamide A (1), along with three known compounds, xylarinol A (2), nectriapyrone (3), and asperisocoumarin A (4), were isolated from the sponge-derived fungus Aspergillus sp. LS53. Their structures were determined by combining detailed spectroscopic analysis and literature data. Compounds 1, 3, and 4 showed weak Vibrio harveyi inhibition with MIC values ranging from 16 to 64 mu g/mL, whereas 2 was found to be inactive.

引用

页码：109 / 111

页数：3

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