Allogeneic islet transplantation with monitoring of islet-specific cellular autoimmunity in a Japanese patient with type 1 diabetes: A case report

被引：0

作者：

Chujo, Daisuke ^{[1
,2
,3
]}

Kurokawa, Toshiaki ^{[4
]}

Kawabe, Akitsu ^{[1
]}

Takahashi, Nobuyuki ^{[2
]}

Inagaki, Fuyuki ^{[5
]}

Shinohara, Koya ^{[1
]}

Hagiwara, Shotaro ^{[6
]}

Edamoto, Yoshihiro ^{[7
]}

Ohmagari, Norio ^{[8
]}

Hinoshita, Fumihiko ^{[9
]}

Tajima, Tsuyoshi ^{[10
]}

Kajio, Hiroshi ^{[2
]}

Ohtsu, Hiroshi ^{[11
]}

Takemura, Nobuyuki ^{[5
]}

Matsumoto, Shinichi ^{[1
]}

Shimoda, Masayuki ^{[1
]}

机构：

[1] Natl Ctr Global Hlth & Med, Res Inst, Pancreat Islet Transplantat Project, Tokyo, Japan

[2] Natl Ctr Global Hlth & Med, Dept Diabet Endocrinol & Metab, Tokyo, Japan

[3] Toyama Univ Hosp, Ctr Clin Res, Toyama, Japan

[4] JCHO Tokyo Takanawa Hosp, Dept Surg, Tokyo, Japan

[5] Natl Ctr Global Hlth & Med, Dept Surg, Hepatobiliary Pancreat Surg Div, Tokyo, Japan

[6] Univ Tsukuba, Fac Med, Tsukuba, Ibaraki, Japan

[7] Secomed Hosp, Dept Surg, Chiba, Japan

[8] Natl Ctr Global Hlth & Med, Dis Control & Prevent Ctr, Tokyo, Japan

[9] Natl Ctr Global Hlth & Med, Nephrol, Tokyo, Japan

[10] Natl Ctr Global Hlth & Med, Radiol, Tokyo, Japan

[11] Natl Ctr Global Hlth & Med, Ctr Clin Sci, Tokyo, Japan

来源：

JOURNAL OF DIABETES INVESTIGATION | 2022年 / 13卷 / 04期

关键词：

Autoimmune response; Type 1 diabetes mellitus; Islet transplantation; T-CELLS;

D O I：

10.1111/jdi.13715

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Here, we report a case of allogeneic islet transplantation in Japan. A 48-year-old man received intraportal islet transplantation (5,945 islet equivalent/kg), and stabilization of blood glucose levels and suppression of hypoglycemia were achieved. In the present case, we used our original assessment method to detect the responses of the recipient's T cells to islet autoantigens over time to monitor cellular autoimmunity. Other markers could not predict graft dysfunction in advance, but our method detected the activation of islet antigen-specific CD8(+) T-cell responses before the deterioration of pancreatic beta-cell function, indicating the possibility of the non-invasive detection of pancreatic beta-cell damage due to recurrent autoimmunity.

引用

页码：741 / 745

页数：5

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