A natural product-like inhibitor of NEDD8-activating enzyme

被引：75

作者：

Leung, Chung-Hang ^{[1
]}

Chan, Daniel Shiu-Hin ^{[2
]}

Yang, Hui ^{[2
]}

Abagyan, Ruben ^{[3
]}

Lee, Simon Ming-Yuen ^{[4
]}

Zhu, Guo-Yuan ^{[1
]}

Fong, Wang-Fun ^{[1
]}

Ma, Dik-Lung ^{[2
]}

机构：

[1] Hong Kong Baptist Univ, Sch Chinese Med, Ctr Canc & Inflammat Res, Kowloon Tong, Hong Kong, Peoples R China

[2] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China

[3] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, San Diego, CA 92103 USA

[4] Univ Macau, Inst Chinese Med Sci, Taipa, Macao, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 09期

关键词：

DISCOVERY; CULLIN; NEDD8; BIFLAVONOIDS; LIGAND;

D O I：

10.1039/c0cc04927a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The natural product-like 6,6 ''-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range.

引用

页码：2511 / 2513

页数：3

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