Histone Deacetylase Inhibitors: New Promise in the Treatment of Immune and Inflammatory Diseases

被引：2

作者：

Shuttleworth, Stephen J. ^{[1
]}

Bailey, Sarah G. ^{[2
]}

Townsend, Paul A. ^{[1
,2
]}

机构：

[1] Karus Therapeut Ltd, Southampton SO16 7NP, Hants, England

[2] Univ Southampton, Div Human Genet, Sch Med, Southampton SO16 6YD, Hants, England

来源：

CURRENT DRUG TARGETS | 2010年 / 11卷 / 11期

关键词：

Histone deacetylases; inhibitors; inflammation; immune disease; FK228; SYSTEMIC-LUPUS-ERYTHEMATOSUS; NITRIC-OXIDE SYNTHASE; VERSUS-HOST-DISEASE; KAPPA-B ACTIVATION; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; ULCERATIVE-COLITIS; BIOLOGICAL-ACTIVITIES; SYNOVIAL FIBROBLASTS; FUNGAL METABOLITE;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The development of Histone Deacetylase (HDAC) inhibitors has, until recently, principally been driven by their potential as anti-cancer agents. However, there is emerging evidence that HDAC inhibitors could have utility in the treatment of chronic immune and inflammatory disorders, including rheumatoid arthritis, psoriasis, inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, airway hyperresponsiveness and organ transplant rejection. Here we discuss the merits of various, structurally-distinct HDAC inhibitors as potential anti-inflammatory therapeutics and provide examples of the novel medicinal chemistry approaches being undertaken to realize HDAC as a druggable target in this clinical setting.

引用

页码：1449 / 1457

页数：9

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