Thermodynamic modelling for solubility of methyl 2-sulfamoylbenzoate in sixteen organic solvents from T (272.15-324.15 K) and dissolution properties

The solubility and solution thermodynamics of methyl 2-sulfamoylbenzoate (MeSAB) in different solvents are essential for the design, optimization and control of its solution crystallization process. In this study, the solubility of MeSAB in sixteen mono solvents including methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, isopentanol, 2-butanone, acetone, ethyl acetate, 2-pentanone, acetonitrile, methyl acetate, ethyl formate and cyclopentanone was obtained through a gravimetric method within the temperature range from 272.15 to 324.15 K under ambient pressure. The highest and lowest solubility of MeSAB was observed in ketones and alcohols, respectively. At fixed temperatures, the solubility data rank as cyclopentanone > acetone > 2-butanone > acetonitrile > 2-pentanone approximate to methyl acetate > ethyl acetate > ethyl formate > methanol > ethanol > n-propanol > isopropanol > n-butanol > n-pentanol > isopentanol approximate to isobutanol. The experimental solubility can be well correlated using the Apelblat equation, lambda h equation, non-random two-liquid (NRTL) model and the Wilson model. The obtained maximum relative average deviation (RAD) and root-mean-square deviation (RMSD) were 6.74 x 10(-3) and 5.61 x 10(-4) respectively. Besides, the dissolution enthalpy, entropy, and Gibbs free energy were calculated on the basis of thermodynamic relations and the Wilson model, which revealed that the dissolution of MeSAB was a spontaneous and endothermic process. (C) 2021 Elsevier B.V. All rights reserved.