Retinal astrocytic hamartoma in tuberous sclerosis complex in an elderly person: a case report

被引:2
作者
Qin, Xiuhong [1 ]
Tao, Yuan [1 ]
Zhang, Zhenzhen [2 ]
机构
[1] Dalian Med Univ, Dept Ophthalmol, Affiliated Hosp 1, 222 Zhongshan Rd, Dalian 116011, Liaoning, Peoples R China
[2] Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Ophthalmol, 639 ZhiZaoJu Rd, Shanghai 200011, Peoples R China
来源
BMC OPHTHALMOLOGY | 2018年 / 18卷
基金
中国国家自然科学基金;
关键词
Tuberous sclerosis complex; TSC; Retinal astrocytic hamartoma; RAH; Astrocytes; Optical coherence tomography; Ophthalmic examination; OPTICAL COHERENCE TOMOGRAPHY;
D O I
10.1186/s12886-018-0991-z
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
BackgroundSpectral domain optical coherence tomography (SD-OCT) is proposed as a way of predicting the development and likelihood of retinal astrocytic hamartoma (RAH) in tuberous sclerosis complex (TSC) in elderly patients.Case presentationThis report describes a case of RAH in TSC in an elderly patient. The patient was a 62-year-old woman and experienced pain in the lower left abdomen for two years. Bilateral renal angiomyolipoma, multiple hepatic angiomyolipoma and multiple pulmonary nodules were demonstrated using computed tomography (CT). Brain CT showed bilateral multiple calcification near by the cella lateralis. A clinical diagnosis of TSC was made. Visual acuity (decimal) in the right and left eye was determined to be 0.6 and 0.8, respectively. SD-OCT revealed a retinal tumour in the inner layer of the retina in the right fundus and a pre-retinal membrane which may have evolved later.ConclusionsA routine ophthalmic examination is advised for patients suspected of having TSC to prevent this condition from being overlooked. In addition, an OCT examination can be used to predict the development and likelihood of RAH.
引用
收藏
页数:4
相关论文
共 12 条
  • [1] Comparison of Color Fundus Photography, Infrared Fundus Photography, and Optical Coherence Tomography in Detecting Retinal Hamartoma in Patients with Tuberous Sclerosis Complex
    Bai, Da-Yong
    Wang, Xu
    Zhao, Jun-Yang
    Li, Li
    Gao, Jun
    Wang, Ning-Li
    [J]. CHINESE MEDICAL JOURNAL, 2016, 129 (10) : 1229 - 1235
  • [2] Barbullushi M, 2002, CLIN NEPHROL, V57, P251
  • [3] Kato A, 2018, EUR J OPHTHALMOL, V1
  • [4] Leung Alexander K C, 2007, J Pediatr Health Care, V21, P108, DOI 10.1016/j.pedhc.2006.05.004
  • [5] OPTICAL COHERENCE TOMOGRAPHY AND INFRARED IMAGES OF ASTROCYTIC HAMARTOMAS NOT REVEALED BY FUNDUSCOPY IN TUBEROUS SCLEROSIS COMPLEX
    Mutolo, Maria G.
    Marciano, Sara
    Benassi, Francesca
    Pardini, Matteo
    Curatolo, Paolo
    Gialloreti, Leonardo Emberti
    [J]. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2017, 37 (07): : 1383 - 1392
  • [6] Tuberous Sclerosis Complex Diagnostic Criteria Update: Recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference
    Northrup, Hope
    Krueger, Darcy A.
    Northrup, Hope
    Krueger, Darcy A.
    Roberds, Steven
    Smith, Katie
    Sampson, Julian
    Korf, Bruce
    Kwiatkowski, David J.
    Mowat, David
    Nellist, Mark
    Northrup, Hope
    Povey, Sue
    de Vries, Petrus
    Byars, Anna
    Dunn, David
    Ess, Kevin
    Hook, Dena
    Jansen, Anna
    King, Bryan
    Sahin, Mustafa
    Whittemore, Vicky
    Thiele, Elizabeth
    Bebin, E. Martina
    Chugani, Harry T.
    Crino, Peter
    Curatolo, Paolo
    Holmes, Greg
    Nabbout, Rima
    O'Callaghan, Finbar
    Wheless, James
    Wu, Joyce
    Darling, Thomas N.
    Cowen, Edward W.
    Gosnell, Elizabeth
    Hebert, Adelaide
    Mlynarczyk, Greg
    Soltani, Keyomaurs
    Teng, Joyce
    Wataya-Kaneda, Mari
    Witman, Patricia M.
    Kingswood, Chris
    Bissler, John
    Budde, Klemens
    Hulbert, John
    Guay-Woodford, Lisa
    Sampson, Julian
    Sauter, Matthias
    Zonneberg, Bernard
    Jozwiak, Sergiusz
    [J]. PEDIATRIC NEUROLOGY, 2013, 49 (04) : 243 - 254
  • [7] DIAGNOSIS OF TUBEROUS SCLEROSIS
    OSBORNE, JP
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD, 1988, 63 (12) : 1423 - 1425
  • [8] RETINAL ASTROCYTIC HAMARTOMA Optical Coherence Tomography Classification and Correlation With Tuberous Sclerosis Complex
    Pichi, Francesco
    Massaro, Domenico
    Serafino, Massimiliano
    Carrai, Paola
    Giuliari, Gian P.
    Shields, Carol L.
    Veronese, Chiara
    Ciardella, Antonio P.
    Nucci, Paolo
    [J]. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2016, 36 (06): : 1199 - 1208
  • [9] Shields CL, 2006, OPHTHALMOLOGY, V113, P1553, DOI 10.1016/j.ophtha.2006.03.032
  • [10] Shields Jerry A, 2004, Trans Am Ophthalmol Soc, V102, P139