Chemokine Decoy Receptors: Structure-Function and Biological Properties

被引：44

作者：

Bonecchi, Raffaella ^{[1
,2
]}

Savino, Benedetta ^{[1
,2
]}

Borroni, Elena M. ^{[1
,2
]}

Mantovani, Alberto ^{[1
,2
]}

Locati, Massimo ^{[1
,2
]}

机构：

[1] Univ Milan, Dept Translat Med, I-20089 Milan, Italy

[2] IRCCS Ist Clin Humanitas, I-20089 Milan, Italy

来源：

CHEMOKINE SYSTEM IN EXPERIMENTAL AND CLINICAL HEMATOLOGY | 2010年 / 341卷

关键词：

DUFFY-ANTIGEN RECEPTOR; PLASMODIUM-VIVAX; CUTTING EDGE; MULTIFACETED ROLES; ENDOTHELIAL-CELLS; PROSTATE-CANCER; MICE LACKING; TUMOR-CELLS; CCX-CKR; D6;

D O I：

10.1007/82_2010_19

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chemokines induce cell migration through the activation of a distinct family of structurally related heterotrimeric G protein-coupled receptors (GPCR). Over the last few years, several receptors in this family that recognize chemokines but do not induce cell migration have been identified. These "atypical" chemokine receptors are unable to activate transduction events that lead directly to cell migration, but appear nonetheless to play a nonredundant role in the control of leukocyte recruitment at inflammatory sites and in tumors by shaping the chemoattractant gradient, either by removing, transporting, or concentrating their cognate ligands.

引用

页码：15 / 36

页数：22

共 107 条

[1] Overexpression of the duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosis [J].

Addison, CL ;

Belperio, JA ;

Burdick, MD ;

Strieter, RM .

BMC CANCER, 2004, 4 (1)

[2] Chemokine: Receptor structure, interactions, and antagonism [J].

Allen, Samantha J. ;

Crown, Susan E. ;

Handel, Tracy M. .

ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 :787-820

[3] The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes [J].

Balabanian, K ;

Lagane, B ;

Infantino, S ;

Chow, KYC ;

Harriague, J ;

Moepps, B ;

Arenzana-Seisdedos, F ;

Thelen, M ;

Bachelerie, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (42) :35760-35766

[4] Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression [J].

Bandyopadhyay, Sucharita ;

Zhan, Rui ;

Chaudhuri, Asok ;

Watabe, Misako ;

Pai, Sudha K. ;

Hirota, Shigeru ;

Hosobe, Sadahiro ;

Tsukada, Taisei ;

Miura, Kunio ;

Takano, Yukio ;

Saito, Ken ;

Pauza, Mary E. ;

Hayashi, Sunao ;

Wang, Ying ;

Mohinta, Sonia ;

Mashimo, Tomoyuki ;

Iiizumi, Megumi ;

Furuta, Eiji ;

Watabe, Kounosuke .

NATURE MEDICINE, 2006, 12 (08) :933-938

[5] The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo [J].

Berres, Marie-Luise ;

Trautwein, Christian ;

Zaldivar, Mirko Moreno ;

Schmitz, Petra ;

Pauels, Katrin ;

Lira, Sergio A. ;

Tacke, Frank ;

Wasmuth, Hermann E. .

BIOLOGICAL CHEMISTRY, 2009, 390 (10) :1039-1045

[6] Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8 [J].

Biber, K ;

Zuurman, MW ;

Homan, H ;

Boddeke, HWGM .

JOURNAL OF LEUKOCYTE BIOLOGY, 2003, 74 (02) :243-251

[7] Purification and biochemical characterization of the D6 chemokine receptor [J].

Blackburn, PE ;

Simpson, CV ;

Nibbs, RJB ;

O'Hara, M ;

Booth, R ;

Poulos, J ;

Isaacs, NW ;

Graham, GJ .

BIOCHEMICAL JOURNAL, 2004, 379 :263-272

[8] Control of chemokine-guided cell migration by ligand sequestration [J].

Boldajipour, Bijan ;

Mahabaleshwar, Harsha ;

Kardash, Elena ;

Reichman-Fried, Michal ;

Blaser, Heiko ;

Minina, Sofia ;

Wilson, Duncan ;

Xu, Qiling ;

Raz, Erez .

CELL, 2008, 132 (03) :463-473

[9] Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor [J].

Bonecchi, R ;

Locati, M ;

Galliera, E ;

Vulcano, M ;

Sironi, M ;

Fra, AM ;

Gobbi, M ;

Vecchi, A ;

Sozzani, S ;

Haribabu, B ;

Van Damme, J ;

Mantovani, A .

JOURNAL OF IMMUNOLOGY, 2004, 172 (08) :4972-4976

[10] Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation [J].

Bonecchi, Raffaella ;

Borroni, Elena M. ;

Anselmo, Achille ;

Doni, Andrea ;

Savino, Benedetta ;

Mirolo, Massimiliano ;

Fabbri, Monica ;

Jala, Venkatakrishna R. ;

Haribabu, Bodduluri ;

Mantovani, Alberto ;

Locati, Massimo .

BLOOD, 2008, 112 (03) :493-503

← 1 2 3 4 5 6 7 8 9 10 →