Leishmanicidal and Trypanocidal Activity of Metal Complexes with 1,2,4-Triazolo[1,5a]pyrimidines: Insights on their Therapeutic Potential against Leishmaniasis and Chagas Disease

被引：28

作者：

Salas, Juan M. ^{[1
]}

Caballero, Ana B. ^{[2
]}

Esteban-Parra, Gines M. ^{[1
]}

Mendez-Arriaga, Jose M. ^{[1
]}

机构：

[1] Univ Granada, Dept Inorgan Chem, Avda Severo Ochoa S-N, E-18071 Granada, Spain

[2] Univ Barcelona, Dept Inorgan & Organ Chem, Marti & Franques 1-11, E-08028 Barcelona, Spain

来源：

CURRENT MEDICINAL CHEMISTRY | 2017年 / 24卷 / 25期

关键词：

Triazolopyrimidine; metal complexes; Leishmania; Trypanosoma cruzi; leishmaniasis; Chagas disease; neglected tropical diseases; TRIAZOLE-PYRIMIDINE COMPLEXES; IN-VITRO; TRYPANOSOMA-CRUZI; BIOLOGICAL-ACTIVITY; TROPICAL DISEASES; LIGAND; MALARIA; INFANTUM; DESIGN; PT(II);

D O I：

10.2174/0929867324666170516122024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since their first synthesis back in the early 20 th century, 1,2,4-triazolo[1,5a] pyrimidines have aroused increasing interest in very diverse areas ranging from chemotherapy to agriculture or even photography. Their similarity to purines confers a potential bioactivity and this feature has been wisely exploited for therapeutic use, including antifungal, antipyretic, analgesic, antiinflammatory, antitumoral and antiparasitic properties. In this review, we focus on the compounds that these nitrogen heterocycles form with metal ions and their antiparasitic activity and therapeutic potential against two neglected diseases of tropical prevalence, leishmaniasis and Chagas disease.

引用

页码：2796 / 2806

页数：11

共 37 条

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