Leishmanicidal and Trypanocidal Activity of Metal Complexes with 1,2,4-Triazolo[1,5a]pyrimidines: Insights on their Therapeutic Potential against Leishmaniasis and Chagas Disease

被引：28

作者：

Salas, Juan M. ^{[1
]}

Caballero, Ana B. ^{[2
]}

Esteban-Parra, Gines M. ^{[1
]}

Mendez-Arriaga, Jose M. ^{[1
]}

机构：

[1] Univ Granada, Dept Inorgan Chem, Avda Severo Ochoa S-N, E-18071 Granada, Spain

[2] Univ Barcelona, Dept Inorgan & Organ Chem, Marti & Franques 1-11, E-08028 Barcelona, Spain

来源：

CURRENT MEDICINAL CHEMISTRY | 2017年 / 24卷 / 25期

关键词：

Triazolopyrimidine; metal complexes; Leishmania; Trypanosoma cruzi; leishmaniasis; Chagas disease; neglected tropical diseases; TRIAZOLE-PYRIMIDINE COMPLEXES; IN-VITRO; TRYPANOSOMA-CRUZI; BIOLOGICAL-ACTIVITY; TROPICAL DISEASES; LIGAND; MALARIA; INFANTUM; DESIGN; PT(II);

D O I：

10.2174/0929867324666170516122024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since their first synthesis back in the early 20 th century, 1,2,4-triazolo[1,5a] pyrimidines have aroused increasing interest in very diverse areas ranging from chemotherapy to agriculture or even photography. Their similarity to purines confers a potential bioactivity and this feature has been wisely exploited for therapeutic use, including antifungal, antipyretic, analgesic, antiinflammatory, antitumoral and antiparasitic properties. In this review, we focus on the compounds that these nitrogen heterocycles form with metal ions and their antiparasitic activity and therapeutic potential against two neglected diseases of tropical prevalence, leishmaniasis and Chagas disease.

引用

页码：2796 / 2806

页数：11

共 37 条

[1] Molecular mechanisms of antimony resistance in Leishmania [J].

Ashutosh ;

Sundar, Shyam ;

Goyal, Neena .

JOURNAL OF MEDICAL MICROBIOLOGY, 2007, 56 (02) :143-153

[2]

Bacchi Cyrus J, 2009, Interdiscip Perspect Infect Dis, V2009, P195040, DOI 10.1155/2009/195040

[3]

Boutaleb-Charki Samira, 2009, Drug Metab Lett, V3, P35

[4] Medicinal organometallic chemistry - an emerging strategy for the treatment of neglected tropical diseases [J].

Brown, Ronald W. ;

Hyland, Christopher J. T. .

MEDCHEMCOMM, 2015, 6 (07) :1230-1243

[5]

Caballero AB, 2014, LEISHMANIASIS - TRENDS IN EPIDEMIOLOGY, DIAGNOSIS AND TREATMENT, P465, DOI 10.5772/57376

[6] Triazolopyrimidine compounds containing first-row transition metals and their activity against the neglected infectious Chagas disease and leishmaniasis [J].

Caballero, Ana B. ;

Rodriguez-Dieguez, Antonio ;

Quiros, Miguel ;

Salas, Juan M. ;

Huertas, Oscar ;

Ramirez-Macias, Inmaculada ;

Olmo, Francisco ;

Marin, Clotilde ;

Chaves-Lemaur, Guillermo ;

Gutierrez-Sanchez, Ramon ;

Sanchez-Moreno, Manuel .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 85 :526-534

[7] Lanthanide complexes containing 5-methyl-1,2,4-triazolo[1,5-a] pyrimidin-7(4H)-one and their therapeutic potential to fight leishmaniasis and Chagas disease [J].

Caballero, Ana B. ;

Rodriguez-Dieguez, Antonio ;

Salas, Juan M. ;

Sanchez-Moreno, Manuel ;

Marin, Clotilde ;

Ramirez-Macias, Inmaculada ;

Santamaria-Diaz, Noelia ;

Gutierrez-Sanchez, Ramon .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2014, 138 :39-46

[8] Toward a New Type of Multifunctional Metal-Organic Systems Based on Nucleobase Analogues: First Results Derived From The Use of Aliphatic α,ω-Dicarboxylates [J].

Caballero, Ana B. ;

Rodriguez-Dieguez, Antonio ;

Lezama, Luis ;

Salas, Juan M. .

CRYSTAL GROWTH & DESIGN, 2012, 12 (07) :3583-3593

[9] Structural consequences of the introduction of 2,2′-bipyrimidine as auxiliary ligand in triazolopyrimidine-based transition metal complexes. In vitro antiparasitic activity [J].

Caballero, Ana B. ;

Marin, Clotilde ;

Ramirez-Macias, Inmaculada ;

Rodriguez-Dieguez, Antonio ;

Quiros, Miguel ;

Salas, Juan M. ;

Sanchez-Moreno, Manuel .

POLYHEDRON, 2012, 33 (01) :137-144

[10] Dinuclear silver(I) complexes for the design of metal-ligand networks based on triazolopyrimidines [J].

Caballero, Ana B. ;

Maclaren, Jana K. ;

Rodriguez-Dieguez, Antonio ;

Vidal, Isaac ;

Dobado, Jose A. ;

Salas, Juan M. ;

Janiak, Christoph .

DALTON TRANSACTIONS, 2011, 40 (44) :11845-11855

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