Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH

被引:439
作者
Yin, Cai-Xia [1 ]
Xiong, Kang-Ming [1 ]
Huo, Fang-Jun [2 ]
Salamanca, James C. [3 ]
Strongin, Robert M. [3 ]
机构
[1] Shanxi Univ, Key Lab Chem Biol & Mol Engn, Minist Educ, Inst Mol Sci,Key Lab Mat Energy Convers & Storage, Taiyuan 030006, Shanxi, Peoples R China
[2] Shanxi Univ, Res Inst Appl Chem, Taiyuan 030006, Shanxi, Peoples R China
[3] Portland State Univ, Dept Chem, Portland, OR 97201 USA
基金
美国国家卫生研究院;
关键词
biothiols; detection methods; fluorescence; imaging; multiple-binding-site probes; HIGHLY SELECTIVE DETECTION; HOMOCYSTEINYL-LYSINE ISOPEPTIDE; ON THIOL PROBE; BLOOD GLUTATHIONE; BIOLOGICAL THIOLS; RECENT PROGRESS; COLORIMETRIC CHEMOSENSORS; OXIDATIVE STRESS; CARBON DOTS; IN-VITRO;
D O I
10.1002/anie.201704084
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Biothiols such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) play crucial roles in maintaining redox homeostasis in biological systems. This Minireview summarizes the most significant current challenges in the field of thiol-reactive probes for biomedical research and diagnostics, emphasizing the needs and opportunities that have been under-investigated by chemists in the selective probe and sensor field. Progress on multiple binding site probes to distinguish Cys, Hcy, and GSH is highlighted as a creative new direction in the field that can enable simultaneous, accurate ratiometric monitoring. New probe design strategies and researcher priorities can better help address current challenges, including the monitoring of disease states such as autism and chronic diseases involving oxidative stress that are characterized by divergent levels of GSH, Cys, and Hcy.
引用
收藏
页码:13188 / 13198
页数:11
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