Chromosome aberrations in workers of nuclear-power plants

被引：36

作者：

Chung, HW ^{[1
]}

Ryu, FK ^{[1
]}

Kim, YJ ^{[1
]}

Ha, SW ^{[1
]}

机构：

[1] SEOUL NATL UNIV,COLL MED,SEOUL 110460,SOUTH KOREA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1996年 / 350卷 / 02期

关键词：

chromosome aberration; nuclear power plant; Poisson regression analysis;

D O I：

10.1016/0027-5107(95)00118-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The frequencies of chromosome aberrations in 135 workers from nuclear-power plants were compared with those in 135 age-matched controls. A total of 135,000 cells was scored. The frequencies of dicentric chromosome were 1.67 x 10(-3) in the exposed group and 0.49 x 10(-3) in the control group and those of chromosome-type deletion were 3.33 X 10(-3) and 1.10 x 10(-3), respectively. The frequencies of all types of chromosome aberrations in the exposed subjects were higher than those in the control group, but no significant trend of dose-dependent increase was observed when only the exposed group were considered. Poisson regression analysis, with both exposed and control included, showed that there was a significant association of chromosome aberration with radiation dose and the duration of work, but not with age, smoking habit and alcohol intake. It was also found that recent exposure to radiation, within the last 5 years, had contributed mure to the observed chromosome aberration than earlier exposure.

引用

页码：307 / 314

页数：8

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