The promise of combining radiation therapy and immunotherapy: morbidity and toxicity

被引：7

作者：

Agassi, Andre M. ^{[1
]}

Myslicki, Francisco A. ^{[1
]}

Shulman, Jesse M. ^{[1
]}

Rotterman, Yosef ^{[1
]}

Dosoretz, Daniel E. ^{[2
]}

Fernandez, Eduardo ^{[3
]}

Mantz, Constantine A. ^{[2
]}

Finkelstein, Steven E. ^{[1
]}

机构：

[1] 21st Century Oncol Translat Res Consortium, Scottsdale, AZ 85251 USA

[2] 21st Century Oncol Translat Res Consortium, Ft Myers, FL USA

[3] 21st Century Oncol Translat Res Consortium, Plantation, FL USA

来源：

FUTURE ONCOLOGY | 2014年 / 10卷 / 15期

关键词：

immunotherapy; radiation; radiation oncology; radiation therapy; radiotherapy; LOCAL RADIATION; TUMOR; MELANOMA; PROSTATE; RADIOSURGERY; RADIOTHERAPY; COMBINATION; IPILIMUMAB; SURVIVAL; VACCINE;

D O I：

10.2217/fon.14.188

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiation therapy and immunotherapy in partnership may have the capability of delivering a therapeutic effect exceeding the sum of its parts. The possible relationship has been demonstrated in murine models and has been extended to a variety of clinical trials. Though the standard notion of whole body radiation therapy is immunosuppressive, there is growing evidence toward the contrary for focal radiation therapy. Furthermore, if immunotherapeutic techniques can retune the immune system against cancerous cells, they should have obvious benefits for advanced treatments moving forward. Herein, we explore the promise in combining radiation therapy and immunotherapy with distinct focus on potential morbidities and toxicities through analysis of completed clinical trials.

引用

页码：2319 / 2328

页数：10

共 36 条

[1] Combinations of Radiation Therapy and Immunotherapy for Melanoma: A Review of Clinical Outcomes [J].

Barker, Christopher A. ;

Postow, Michael A. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2014, 88 (05) :986-997

[2] Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma [J].

Chi, KW ;

Liu, SD ;

Li, CP ;

Kuo, HP ;

Wang, YS ;

Chao, Y ;

Hsieh, SL .

JOURNAL OF IMMUNOTHERAPY, 2005, 28 (02) :129-135

[3]

Ferrara TA, 2009, CURR OPIN MOL THER, V11, P37

[4]

Finkelstein S.E, 2012, ISRN IMMUNOL, V2012, DOI [10.5402/2012/324235, DOI 10.5402/2012/324235]

[5]

Finkelstein S E, 2011, INT J CLIN REV, DOI [10.5275/ijcr.2011.12.10, DOI 10.5275/IJCR.2011.12.10]

[6] Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer [J].

Finkelstein, SE ;

Heimann, DM ;

Klebanoff, CA ;

Antony, PA ;

Gattinoni, L ;

Hinrichs, CS ;

Hwang, LN ;

Palmer, DC ;

Spiess, PJ ;

Surman, DR ;

Wrzesiniski, C ;

Yu, ZY ;

Rosenberg, SA ;

Restifo, NP .

JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 76 (02) :333-337

[7] Clinicalopportunitiesincombiningimmunotherapywithradiationtherapy [J].

Finkelstein, Steven E. ;

Fishman, Mayer .

FRONTIERS IN ONCOLOGY, 2012, 2

[8] COMBINATION OF EXTERNAL BEAM RADIOTHERAPY (EBRT) WITH INTRATUMORAL INJECTION OF DENDRITIC CELLS AS NEO-ADJUVANT TREATMENT OF HIGH-RISK SOFT TISSUE SARCOMA PATIENTS [J].

Finkelstein, Steven E. ;

Iclozan, Cristina ;

Bui, Marilyn M. ;

Cotter, Matthew J. ;

Ramakrishnan, Rupal ;

Ahmed, Jamil ;

Noyes, David R. ;

Cheong, David ;

Gonzalez, Ricardo J. ;

Heysek, Randy V. ;

Berman, Claudia ;

Lenox, Brianna C. ;

Janssen, William ;

Zager, Jonathan S. ;

Sondak, Vernon K. ;

Letson, G. Douglas ;

Antonia, Scott J. ;

Gabrilovich, Dmitry I. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 82 (02) :924-932

[9]

Finkelstein SE, 2012, IMMUNOTHERAPY-UK, V4, P373, DOI [10.2217/imt.12.24, 10.2217/IMT.12.24]

[10] The Confluence of Stereotactic Ablative Radiotherapy and Tumor Immunology [J].

Finkelstein, Steven Eric ;

Timmerman, Robert ;

McBride, WilliamH. ;

Schaue, Doerthe ;

Hoffe, Sarah E. ;

Mantz, Constantine A. ;

Wilson, George D. .

CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2011,

← 1 2 3 4 →