Effects of oat soluble and insoluble -glucan on 1,2-dimethylhydrazine-induced early colon carcinogenesis in mice

被引：25
作者：
Shen, Rui-Ling [1 ,2 ]
Wang, Zhen [1 ,2 ]
Dong, Ji-Lin [1 ,2 ]
Xiang, Qi-Sen [1 ,2 ]
Liu, Yan-Qi [1 ,2 ]
机构：
[1] Zhengzhou Univ Light Ind, Sch Food & Bioengn, Zhengzhou, Henan, Peoples R China
[2] Collaborat Innovat Ctr Food Prod & Safety, Zhengzhou, Henan, Peoples R China
来源：
FOOD AND AGRICULTURAL IMMUNOLOGY | 2016年 / 27卷 / 05期
关键词：
Oat; -glucan; colon cancer; apoptosis; SCFA; mice; DIETARY FIBER COMPONENTS; BILE-ACIDS; HEALTH-BENEFITS; CANCER RISK; FERMENTATION; MECHANISMS; MICROBIOTA; BARLEY; STARCH; RATS;
D O I：
10.1080/09540105.2016.1148664
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The study is aimed at studying the effects of soluble and insoluble oat -glucan on colon carcinogenesis in mice. One hundred and twenty male Kunming mice were divided into normal control (NC), model control (MC), high doses (100mg/kg body weight) of soluble (H-SOG) and insoluble -glucan (H-IOG), and low doses (50mg/kg body weight) of soluble (L-SOG) and insoluble -glucan (L-IOG) groups. The mice except those in the NC group were given subcutaneous injections of DMH to induce colon cancer. The bile acid content was significantly reduced but the colonic short-chain fatty acid content was enhanced (p<.05) in mice administered -glucan, moreover, the tumor cells apoptosis was significantly promoted (p<.05), compared to the MC group. The effect of high doses -glucan was better than the low doses, but there is little difference between the SOG and IOG. Results suggested that both SOG and IOG exert favorable effects in preventing colon cancer in a doses-dependent manner while the specific mechanism maybe different.
引用
收藏
页码：657 / 666
页数：10
相关论文
共 50 条
  • [31] Precancerous ACF induction affects their regional distribution forsaking oxidative stress implication in 1,2-dimethylhydrazine-induced colon carcinogenesis model
    Hichem Moulahoum
    Andras-Laszlo Nagy
    Bahia Djerdjouri
    Simona Clichici
    Inflammopharmacology, 2018, 26 : 457 - 468
  • [32] Precancerous ACF induction affects their regional distribution forsaking oxidative stress implication in 1,2-dimethylhydrazine-induced colon carcinogenesis model
    Moulahoum, Hichem
    Nagy, Andras-Laszlo
    Djerdjouri, Bahia
    Clichici, Simona
    INFLAMMOPHARMACOLOGY, 2018, 26 (02) : 457 - 468
  • [33] Chemoprevention of 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis by a Non-Steroidal Anti-Inflammatory Drug, Etoricoxib, in Rats: Inhibition of Nuclear Factor κB
    Tanwar, Lalita
    Vaish, Vivek
    Sanyal, S. N.
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2009, 10 (06) : 1141 - 1146
  • [34] Modulation of JNK-1/ β-catenin signaling by Lactobacillus casei, inulin and their combination in 1,2-dimethylhydrazine-induced colon cancer in mice
    Ali, Mohammed S.
    Hussein, Rasha M.
    Gaber, Yasser
    Hammam, Olfat A.
    Kandeil, Mohamed A.
    RSC ADVANCES, 2019, 9 (50) : 29368 - 29383
  • [35] INFLUENCE OF DIETARY CALCIUM AND VITAMIN-D ON COLON EPITHELIAL-CELL PROLIFERATION AND 1,2-DIMETHYLHYDRAZINE-INDUCED COLON CARCINOGENESIS IN RATS FED HIGH-FAT DIETS
    BEATY, MM
    LEE, EY
    GLAUERT, HP
    JOURNAL OF NUTRITION, 1993, 123 (01) : 144 - 152
  • [36] Long-term treatment with Sitagliptin, a dipeptidyl peptidase-4 inhibitor, reduces colon carcinogenesis and reactive oxygen species in 1,2-dimethylhydrazine-induced rats
    Femia, Angelo Pietro
    Raimondi, Laura
    Maglieri, Giulia
    Lodovici, Maura
    Mannucci, Edoardo
    Caderni, Giovanna
    INTERNATIONAL JOURNAL OF CANCER, 2013, 133 (10) : 2498 - 2503
  • [37] Effects of high molybdenum intake on 1,2-dimethylhydrazine-induced intestinal tumors in rats
    Montenegro, MA
    Negrette, MS
    Gimeno, EJ
    Borda, JT
    BIOCELL, 2002, 26 (03) : 339 - 345
  • [38] Protective role of luteolin in 1,2-dimethylhydrazine induced experimental colon carcinogenesis
    Manju, V.
    Nalini, N.
    CELL BIOCHEMISTRY AND FUNCTION, 2007, 25 (02) : 189 - 194
  • [39] The modulatory effects of exercise on the inflammatory and apoptotic markers in rats with 1,2-dimethylhydrazine-induced colorectal cancer
    Darband, Saber Ghazizadeh
    Saboory, Ehsan
    Sadighparvar, Shirin
    Kaviani, Mojtaba
    Mobaraki, Kazhal
    Jabbari, Nasrollah
    Majidinia, Maryam
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2020, 98 (03) : 147 - 155
  • [40] Immunohistochemical localization of prostaglandin endoperoxide G/H synthase isozymes in the normal rat colon epithelium and in 1,2-dimethylhydrazine-induced colon tumours
    Barnes, CJ
    Cameron, IL
    Lee, M
    GI CANCER, 1998, 2 (04): : 329 - +
12345