Evaluation of ischemic diabetic maculopathy with Fourier-domain optical coherence tomography and microperimetry

Objective: To evaluate the efficacy of high-speed Fourier-domain optical coherence tomography (FD-OCT) and fundus m croperimetry (MP-1) in identifying the anatomic and functional features of ischemic diabetic maculopathy. Design: Prospective noninterventional study. Participants: Forty-two consecutive eyes (23 patients) with ischemic diabetic maculopathy and 40 normal eyes (25 control subjects) were included in this study. Methods: Best corrected visual acuity, ganglion cell complex (GCC) thickness measured with FD-OCT, and central light sensitivity recorded with MP-1 were evaluated. Results: GCC thickness and light sensitivity were significantly reduced in all affected eyes versus control eyes. logMAR BVCA was significantly correlated with mean macular sensitivity (R = 0.783, R-2 = 0.611). Conclusions: GCC thickness and microperimetry integrated with fluorescein angiography could be a marker of retinal vascular abnormalities that is useful for the diagnosis of schemic diabetic maculopathy.