Time to Harmonize Dengue Nomenclature and Classification

被引：13

作者：

Cuypers, Lize ^{[1
,2
]}

Libin, Pieter J. K. ^{[1
,3
]}

Simmonds, Peter ^{[2
]}

Nowe, Ann ^{[3
]}

Munoz-Jordan, Jorge ^{[4
]}

Junior Alcantara, Luiz Carlos ^{[5
]}

Vandamme, Anne-Mieke ^{[1
,6
]}

Santiago, Gilberto A. ^{[4
]}

Theys, Kristof ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res Clin & Epidemiol Virol, Dept Microbiol & Immunol, B-3000 Louvain, Belgium

[2] Univ Oxford, Nuffield Dept Med, Oxford OX1 3SY, England

[3] Vrije Univ Brussel, Dept Comp Sci, Artificial Intelligence Lab, B-1050 Brussels, Belgium

[4] Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Dis, San Juan, PR 00920 USA

[5] Fiocruz MS, Inst Oswaldo Cruz, Lab Flavivirus, BR-21040360 Rio De Janeiro, Brazil

[6] Univ Nova Lisboa, Inst Higiene & Med Trop, Unidade Microbiol, Global Hlth & Trop Med, P-1349008 Lisbon, Portugal

来源：

VIRUSES-BASEL | 2018年 / 10卷 / 10期

基金：

欧盟地平线“2020”;

关键词：

dengue virus; classification; nomenclature; diversity; VIRUS EVOLUTION; VIRULENCE; TRANSMISSION; BURDEN; TYPE-1;

D O I：

10.3390/v10100569

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Dengue virus (DENV) is estimated to cause 390 million infections per year worldwide. A quarter of these infections manifest clinically and are associated with a morbidity and mortality that put a significant burden on the affected regions. Reports of increased frequency, intensity, and extended geographical range of outbreaks highlight the virus's ongoing global spread. Persistent transmission in endemic areas and the emergence in territories formerly devoid of transmission have shaped DENV's current genetic diversity and divergence. This genetic layout is hierarchically organized in serotypes, genotypes, and sub-genotypic clades. While serotypes are well defined, the genotype nomenclature and classification system lack consistency, which complicates a broader analysis of their clinical and epidemiological characteristics. We identify five key challenges: (1) Currently, there is no formal definition of a DENV genotype; (2) Two different nomenclature systems are used in parallel, which causes significant confusion; (3) A standardized classification procedure is lacking so far; (4) No formal definition of sub-genotypic clades is in place; (5) There is no consensus on how to report antigenic diversity. Therefore, we believe that the time is right to re-evaluate DENV genetic diversity in an essential effort to provide harmonization across DENV studies.

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