Reaction of caffeic acid derivatives with acidic nitrite

被引：31
作者：
Cotelle, P [1 ]
Vezin, H [1 ]
机构：
[1] Univ Lille 1, ENSCL, CNRS, Chim Organ Phys Lab, F-59655 Villeneuve Dascq, France
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 19期
关键词：
nitrous acid and derivatives; nitro compounds; neolignans;
D O I：
10.1016/S0040-4039(01)00441-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Caffeic derivatives were reacted with acidic nitrite at controlled pH in order to mimic the gastric juice conditions. At pH 2, whereas caffeic acid reacts exclusively on the side chain, its esters are readily nitrated. Under more acidic conditions (pH 1), caffeic acid methyl ester undergoes a dimerisation into a norlignan derivative. (C) 2001 Published by Elsevier Science Ltd.
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收藏
页码：3303 / 3305
页数：3
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