Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 to prevent or cure bacterial vaginosis among women with HIV

被引：63

作者：

Hummelen, Ruben ^{[1
,2
]}

Changalucha, John ^{[3
]}

Butamanya, Nicodemus L. ^{[4
]}

Cook, Adrian ^{[5
]}

Habbema, J. Dik F. ^{[2
]}

Reid, Gregor ^{[1
,6
,7
]}

机构：

[1] Canadian Res & Dev Ctr Probiot, Lawson Hlth Res Inst, London, ON N6A 4V2, Canada

[2] Univ Med Ctr Rotterdam, Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands

[3] Mwanza Res Ctr, Natl Inst Med Res, Mwanza, Tanzania

[4] Sekou Toure Reg Hosp, Mwanza, Tanzania

[5] Kivulini Womens Rights Org, Mwanza, Tanzania

[6] Univ Western Ontario, Dept Microbiol, London, ON, Canada

[7] Univ Western Ontario, Dept Immunol & Surg, London, ON, Canada

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 2010年 / 111卷 / 03期

关键词：

Bacterial vaginosis; HIV; Metronidazole; Probiotics; Supplementation; VAGINAL FLORA; DOUBLE-BLIND; TRACT; THERAPY; SAFETY;

D O I：

10.1016/j.ijgo.2010.07.008

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To assess, among women with HIV, whether long-term oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 supplementation can prevent bacterial vaginosis (BV) and enhance the cure rate of metronidazole among those with BV. Methods: A randomized, double-blind, placebo-controlled trial conducted among 65 HIV-infected women with an aberrant microbiota (Nugent score 4-10) who were randomized to receive daily probiotics or placebo for 6 months. Those with BV (Nugent score 7-10) additionally received metronidazole for 10 days (400 mg twice daily). Results: We did not find an enhanced cure rate of BV among women with HIV treated with adjuvant probiotics to metronidazole treatment. Among women with an intermediate vaginal flora, probiotics tended to increase the probability of a normal vaginal flora (odds ratio 2.4; P=0.1) and significantly increased the probability of a beneficial vaginal pH (odds ratio 3.8; P=0.02) at follow-up. Conclusion: Supplementation of probiotic L rhamnosus GR-1 and L. reuteri RC-14 did not enhance the cure of BV among women living with HIV, but may prevent the condition among this population. Trial registration: NCT00536848. (C) 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：245 / 248

页数：4

共 18 条

[1] Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14:: randomized, double-blind, placebo controlled trial [J].

Anukam, Kingsley ;

Osazuwa, Emmanuel ;

Ahonkhai, Jeoma ;

Ngwu, Michael ;

Osemene, Gibson ;

Bruce, Andrew W. ;

Reid, Gregor .

MICROBES AND INFECTION, 2006, 8 (06) :1450-1454

[2] Probiotics and immune response [J].

Cunningham-Rundles, S ;

Ahrné, S ;

Bengmark, S ;

Johann-Liang, R ;

Marshall, F ;

Metakis, L ;

Califano, C ;

Dunn, AM ;

Grassey, C ;

Hinds, G ;

Cervia, J .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2000, 95 (01) :S22-S25

[3] THE NORMAL VAGINAL FLORA, H2O2-PRODUCING LACTOBACILLI, AND BACTERIAL VAGINOSIS IN PREGNANT-WOMEN [J].

HILLIER, SL ;

KROHN, MA ;

RABE, LK ;

KLEBANOFF, SJ ;

ESCHENBACH, DA .

CLINICAL INFECTIOUS DISEASES, 1993, 16 :S273-S281

[4] Bacterial vaginosis: Review of treatment options and potential clinical indications for therapy [J].

Joesoef, MR ;

Schmid, GP ;

Hillier, SL .

CLINICAL INFECTIOUS DISEASES, 1999, 28 :S57-S65

[5] Utilization of the intestinal tract as a delivery system for urogenital Probiotics [J].

Morelli, L ;

Zonenenschain, D ;

Del Piano, M ;

Cognein, P .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2004, 38 (06) :S107-S110

[6] Randomized, double-blind, placebo-controlled study of oral lactobacilli to improve the vaginal flora of postmenopausal women [J].

Petricevic, Ljubomir ;

Unger, Frank M. ;

Viernstein, Helmut ;

Kiss, Herbert .

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2008, 141 (01) :54-57

[7] Oral use of Lactobacillus rhamnosus GR-1 and L-fermentum RC-14 significantly alters vaginal flora:: randomized, placebo-controlled trial in 64 healthy women [J].

Reid, G ;

Charbonneau, D ;

Erb, J ;

Kochanowski, B ;

Beuerman, D ;

Poehner, R ;

Bruce, AW .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2003, 35 (02) :131-134

[8] Nucleic acid-based diagnosis of bacterial vaginosis and improved management using probiotic lactobacilli [J].

Reid, G ;

Burton, J ;

Hammond, JA ;

Bruce, AW .

JOURNAL OF MEDICINAL FOOD, 2004, 7 (02) :223-228

[9] Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora [J].

Reid, G ;

Beuerman, D ;

Heinemann, C ;

Bruce, AW .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2001, 32 (01) :37-41

[10] The efficacy and safety of probiotic Lactobacillus rhamnosus GG on prolonged, noninfectious diarrhea in HIV patients on antiretroviral therapy:: A randomized, placebo-controlled, crossover study [J].

Salminen, MK ;

Tynkkynen, S ;

Rautelin, H ;

Poussa, T ;

Saxelin, M ;

Ristola, M ;

Valtonen, V ;

Järvinen, A .

HIV CLINICAL TRIALS, 2004, 5 (04) :183-191

← 1 2 →