Computed Tomography Screening for Lung Cancer in the National Lung Screening Trial A Cost-effectiveness Analysis

被引：23

作者：

Black, William C. ^{[1
]}

机构：

[1] Dartmouth Hitchcock Med Ctr, Geisel Sch Med Dartmouth, Dept Radiol, Lebanon, NH 03755 USA

来源：

JOURNAL OF THORACIC IMAGING | 2015年 / 30卷 / 02期

关键词：

cost-benefit analysis; early diagnosis; lung neoplasms/mortality/radiography; mass screening/economics/methods; quality-adjusted life-years; randomized controlled trials as topic; tomography; spiral computed/methods; SERVICES TASK-FORCE; QUALITY-OF-LIFE; INCIDENTAL FINDINGS; HEALTH; MORTALITY; OVERDIAGNOSIS; POPULATION; STRATEGIES; BENEFITS; CRITERIA;

D O I：

10.1097/RTI.0000000000000136

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The National Lung Screening Trial (NLST) demonstrated that screening with low-dose CT versus chest radiography reduced lung cancer mortality by 16% to 20%. More recently, a cost-effectiveness analysis (CEA) of CT screening for lung cancer versus no screening in the NLST was performed. The CEA conformed to the reference-case recommendations of the US Panel on Cost-Effectiveness in Health and Medicine, including the use of the societal perspective and an annual discount rate of 3%. The CEA was based on several important assumptions. In this paper, I review the methods and assumptions used to obtain the base case estimate of $81,000 per quality-adjusted life-year gained. In addition, I show how this estimate varied widely among different subsets and when some of the base case assumptions were changed and speculate on the cost-effectiveness of CT screening for lung cancer outside the NLST.

引用

页码：79 / 87

页数：9

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