N(4)-tolyl-2-benzoylpyridine-derived thiosemicarbazones and their palladium(II) platinum(II) complexes: Cytotoxicity against human solid tumor cells

被引：38

作者：

Ferraz, Karina O. S. ^{[1
]}

Cardoso, Gabriele M. M. ^{[2
]}

Bertollo, Caryne Margotto ^{[2
]}

Souza-Fagundes, Elaine M. ^{[2
]}

Speziali, Nivaldo ^{[3
]}

Zani, Carlos L. ^{[4
]}

Mendes, Isolda C. ^{[1
]}

Gomes, Maria A. ^{[5
]}

Beraldo, Heloisa ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Fisiol & Biofis, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Dept Fis, BR-31270901 Belo Horizonte, MG, Brazil

[4] Fiocruz MS, Ctr Pesquisas Rene Rachou, Belo Horizonte, MG, Brazil

[5] Univ Fed Minas Gerais, Dept Parasitol, BR-31270901 Belo Horizonte, MG, Brazil

来源：

POLYHEDRON | 2011年 / 30卷 / 02期

关键词：

Thiosemicarbazones; Platinum(II) complexes; Solid tumor; RIBONUCLEOTIDE REDUCTASE; TOXICITY; INHIBITOR; ASSAY; EXPRESSION; GROWTH; MTT;

D O I：

10.1016/j.poly.2010.10.014

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Complexes [Pt(2Bz4oT)Cl], [Pt(2Bz4mT)Cl], and [Pt(2Bz4pT)Cl] were prepared with N(4)-ortho-(H2Bz4oT), N(4)-meta-(H2Bz4mT), and N(4)-para-(H2Bz4pT) tolyl-2-benzoylpyridine-derived thiosemicarbazones. The thiosemicarbazones exhibited moderate anti-proliferative activity against HepG2 (hepatoma) and UACC-62 (melanoma) cancer cell lines, but showed high anti-proliferative effect against A431 (epithelial carcinoma) cancer cell lines. Upon coordination to platinum(II) the anti-proliferative activity decreases in all cases. The cytotoxicity of the previously prepared palladium(II) analogues [Pd(2Bz4oT)Cl], [Pd(2Bz4mT)Cl], and [Pd(2Bz4pT)Cl] was also investigated. As in the case of the platinum(II) complexes, coordination to palladium(II) did not lead to activity improvement. Investigations on the mechanism of cytotoxic action against A431 cells revealed that [Pd(2Bz4oT)Cl] induced DNA fragmentation and apoptosis while H2Bz4oT did not present this effect. The high anti-proliferative effect of the thiosemicarbazones and [Pd(2Bz4oT)Cl] against A431 cells, together with the pro-apoptotic effect of [Pd(2Bz4oT)Cl] suggests that these compounds have potential as chemotherapeutic drug candidates. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：315 / 321

页数：7

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