A new view of V(D)J recombination

被引：20
作者：
Gellert, M [1 ]
机构：
[1] NIDDKD,MOL BIOL LAB,BETHESDA,MD 20892
来源：
GENES TO CELLS | 1996年 / 1卷 / 03期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1046/j.1365-2443.1996.22023.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The DNA rearrangement that assembles antibody and T cell receptor genes is beginning to be understood. New work shows that the first step is a site-specific cleavage which can be performed by purified RAG1 and RAG2 proteins. The later steps largely overlap with the repair of radiation-induced DNA double-strand breaks, as indicated by the identity of several newly cloned factors. These developments open the way for a thorough biochemical study of V(D)J recombination.
引用
收藏
页码：269 / 275
页数：7
相关论文
共 40 条
  • [1] SCID MUTATION IN MICE CONFERS HYPERSENSITIVITY TO IONIZING-RADIATION AND A DEFICIENCY IN DNA DOUBLE-STRAND BREAK REPAIR
    BIEDERMANN, KA
    SUN, JR
    GIACCIA, AJ
    TOSTO, LM
    BROWN, JM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) : 1394 - 1397
  • [2] DEFECTIVE DNA-DEPENDENT PROTEIN-KINASE ACTIVITY IS LINKED TO V(D)J RECOMBINATION AND DNA-REPAIR DEFECTS ASSOCIATED WITH THE MURINE SCID MUTATION
    BLUNT, T
    FINNIE, NJ
    TACCIOLI, GE
    SMITH, GCM
    DEMENGEOT, J
    GOTTLIEB, TM
    MIZUTA, R
    VARGHESE, AJ
    ALT, FW
    JEGGO, PA
    JACKSON, SP
    [J]. CELL, 1995, 80 (05) : 813 - 823
  • [3] AN ACTIVE V-ABL PROTEIN-TYROSINE KINASE BLOCKS IMMUNOGLOBULIN LIGHT-CHAIN GENE REARRANGEMENT
    CHEN, YY
    WANG, LC
    HUANG, MS
    ROSENBERG, N
    [J]. GENES & DEVELOPMENT, 1994, 8 (06) : 688 - 697
  • [4] ANALYSIS OF REGIONS OF RAG-2 IMPORTANT FOR V(D)J RECOMBINATION
    CUOMO, CA
    OETTINGER, MA
    [J]. NUCLEIC ACIDS RESEARCH, 1994, 22 (10) : 1810 - 1814
  • [5] HIV-1 DNA INTEGRATION - MECHANISM OF VIRAL-DNA CLEAVAGE AND DNA STRAND TRANSFER
    ENGELMAN, A
    MIZUUCHI, K
    CRAIGIE, R
    [J]. CELL, 1991, 67 (06) : 1211 - 1221
  • [6] THE SCID MUTATION IN MICE CAUSES A GENERAL DEFECT IN DNA-REPAIR
    FULOP, GM
    PHILLIPS, RA
    [J]. NATURE, 1990, 347 (6292) : 479 - 482
  • [7] GELLERT M, 1992, ANNU REV GENET, V22, P425
  • [8] DNA-DEPENDENT PROTEIN-KINASE CATALYTIC SUBUNIT - A RELATIVE OF PHOSPHATIDYLINOSITOL 3-KINASE AND THE ATAXIA-TELANGIECTASIA GENE-PRODUCT
    HARTLEY, KO
    GELL, D
    SMITH, GCM
    ZHANG, H
    DIVECHA, N
    CONNELLY, MA
    ADMON, A
    LEESMILLER, SP
    ANDERSON, CW
    JACKSON, SP
    [J]. CELL, 1995, 82 (05) : 849 - 856
  • [9] A LINK BETWEEN DOUBLE-STRAND BREAK-RELATED REPAIR AND V(D)J RECOMBINATION - THE SCID MUTATION
    HENDRICKSON, EA
    QIN, XQ
    BUMP, EA
    SCHATZ, DG
    OETTINGER, M
    WEAVER, DT
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) : 4061 - 4065
  • [10] DNA-DEPENDENT KINASE (P350) AS A CANDIDATE GENE FOR THE MURINE SCID DEFECT
    KIRCHGESSNER, CU
    PATIL, CK
    EVANS, JW
    CUOMO, CA
    FRIED, LM
    CARTER, T
    OETTINGER, MA
    BROWN, JM
    [J]. SCIENCE, 1995, 267 (5201) : 1178 - 1183
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