Virus-like particles for drug delivery: a review of methods and applications

被引：43

作者：

Ikwuagwu, Bon ^{[1
]}

Tullman-Ercek, Danielle ^{[1
,2
]}

机构：

[1] Northwestern Univ, Dept Chem & Biol Engn, 2145 Sheridan Rd,Technol Inst E136, Evanston, IL 60208 USA

[2] Northwestern Univ, Ctr Synthet Biol, 2145 Sheridan Rd,Technol Inst B486, Evanston, IL 60208 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2022年 / 78卷

基金：

美国国家科学基金会;

关键词：

TOBACCO-MOSAIC-VIRUS; NANOPARTICLES; MUTANT;

D O I：

10.1016/j.copbio.2022.102785

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Virus-like particles (VLPs) are self-assembling protein nanoparticles that have great promise as vectors for drug delivery. VLPs are derived from viruses but retain none of their infection or replication capabilities. These protein particles have defined surface chemistries, uniform sizes, and stability properties that make them attractive starting points for drug -delivery scaffolds. Here, we review recent advances in tailoring VLPs for drug-delivery applications, including VLP platform engineering approaches as well as methods for cargo loading, activation, and release. Finally, we highlight several successes using VLPs for drug delivery in model systems.

引用

页数：7

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