Efficacy, safety and effectiveness of ondansetron compared to other serotonin-3 receptor antagonists (5-HT3RAs) used to control chemotherapy-induced nausea and vomiting: systematic review and meta-analysis

被引：12

作者：

Rezende Simino, Giovana Paula ^{[1
]}

Marra, Lays Pires ^{[2
]}

Gurgel de Andrade, Eli Iola ^{[3
]}

Acurcio, Francisco de Assis ^{[2
]}

Reis, Ilka Afonso ^{[4
]}

De Araujo, Vania Eloisa ^{[5
]}

Cherchiglia, Mariangela Leal ^{[6
]}

机构：

[1] Univ Fed Minas Gerais, Sch Nursing, Basic Nursing Dept, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Social Pharm Dept, Fac Pharm, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Sch Med, Prevent & Social Med, Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Dept Stat, Exact Sci Inst, Belo Horizonte, MG, Brazil

[5] Pontificia Univ Catolica Minas Gerais, Dept Dent, Belo Horizonte, MG, Brazil

[6] Univ Fed Minas Gerais, Prevent & Social Med, Sch Med, Belo Horizonte, MG, Brazil

来源：

EXPERT REVIEW OF CLINICAL PHARMACOLOGY | 2016年 / 9卷 / 09期

关键词：

Chemotherapy; nausea; vomiting; pharmacology; symptom management; systematic review; meta-analysis; 5-HT3 antagonist serotonin; ondansetron and granisetron; MODERATELY EMETOGENIC CHEMOTHERAPY; DOSE ORAL GRANISETRON; QUALITY-OF-LIFE; DOUBLE-BLIND; INTRAVENOUS ONDANSETRON; ANTIEMETIC EFFICACY; INDUCED EMESIS; PHASE-III; DOLASETRON MESYLATE; RANDOMIZED-TRIAL;

D O I：

10.1080/17512433.2016.1190271

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Introduction: Chemotherapy-induced nausea and vomiting are adverse effects responsible for worsening quality of life in cancer patients. To assess the efficacy, safety and effectiveness of serotonin receptor antagonist in cancer patients undergoing chemotherapy, comparing ondansetron with granisetron, dolasetron, tropisetron and palonosetron.Areas covered: Systematic review and meta-analysis. The data were collected using CINAHL; CENTRAL; MEDLINE/PubMed; and LILACS databases; grey literature; and manual search. The methodological quality was assessed using the modified Jadad scale; Cochrane Collaboration's tool for assessing risk of bias in randomized clinical trials and the Newcastle-Ottawa Scale for observational studies. The search was completed in November, 2015. 26 studies were included in the meta-analysis. Ondansetron exhibited similar efficacy than granisetron and tropisetron, as well as greater efficacy than dolasetron for acute vomiting. Palonosetron exhibited greater efficacy than ondansetron for delayed nausea and acute and delayed vomiting. The comparison of granisetron with ondansetron in the cohort studies showed no difference.Expert commentary: In this review, palonosetron had increased efficiency compared with ondansetron, except in the subgroup analysis and acute nausea. Few cohort studies have been published addressing this topic.

引用

页码：1183 / 1194

页数：12

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