Epidemiology, pathophysiology, and management of uric acid urolithiasis: A narrative review

被引:84
|
作者
Abou-Elela, A. [1 ]
机构
[1] Cairo Univ, Fac Med, Dept Urol, Kasr Al Ainy St,PO 11553, Cairo 11562, Egypt
关键词
Urolithiasis; Calculi; Uric acid; Urinary stones; Uric acid stones; pH dissolution; Nephrolithiasis; Chemolysis; CALCIUM-OXALATE MONOHYDRATE; SHOCK-WAVE LITHOTRIPSY; URINARY STONE ANALYSIS; LOW-DOSE CT; BIOCHEMICAL PROFILE; DIURNAL-VARIATION; RANDALLS PLAQUE; UNITED-STATES; KIDNEY-STONES; RISK-FACTORS;
D O I
10.1016/j.jare.2017.04.005
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
An in-depth comprehension of the epidemiology as well as pathophysiology of uric acid urolithiasis is important for the identification, treatment, and prophylaxis of calculi in these patients. Persistently low urinary pH, hyperuricosuria, and low urinary volume are the most important factors in pathogenesis of uric acid urolithiasis. Other various causes of calculus formation comprises of chronic diarrhea, renal hyperuricosuria, insulin resistance, primary gout, extra purine in the diet, neoplastic syndromes, and congenital hyperuricemia. Non-contrast-enhanced computed tomography is the radiologic modality of choice for early assessment of patients with renal colic. Excluding situations where there is acute obstruction, rising blood chemistry, severe infection, or unresolved pain, the initial management ought to be medical dissolution by oral chemolysis since this method has proved to be effective in most of the cases. (C) 2017 Production and hosting by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license
引用
收藏
页码:513 / 527
页数:15
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