A plausible prebiotic selection of ribose forRNA-formation, dynamic isolation, andnucleotide synthesis based on metal-doped-clays

被引：16

作者：

Zhao, Ze-Run ^{[1
]}

Wang, Xiao ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, 163 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China

来源：

CHEM | 2021年 / 7卷 / 12期

基金：

中国国家自然科学基金;

关键词：

PULSED AMPEROMETRIC DETECTION; EXCHANGE CHROMATOGRAPHY; CHEMICAL ETIOLOGY; FORMOSE REACTION; ORIGIN; RNA; SUGARS; COMPLEXES; CHEMISTRY; SILICATE;

D O I：

10.1016/j.chempr.2021.09.002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The natural selection of ribose as the exclusive sugar for RNA hasbeen one of the greatest puzzlesin the origins of life. Here, wepresent a plausible solution to this problem that circumvents thelimitations of previous hypotheses, inspired by the unique retentionproperties of ribose in ligand-exchange chromatography. It isdiscovered that metal cations and clay minerals have a synergisticeffect to selectively bind to ribose against other monosaccharides.Excitingly, ribose can be continuously and highly selectively en-riched on metal-doped-clays (MDCs) from a complex Formosemixture, which could be the origin of its rise to prominence. Prebi-otic scenarios of the dynamic isolation of ribose from sugar mixtureare simulated with microflow technology. The MDC-retained riboseexhibits long-term stability for the upcoming nucleosidation reac-tions. Computational studies helpelucidate the unique stability ofthe ribose-MDC complex.MDCalsopromotesthe50-phosphoryla-tion of nucleosides with greater yield and selectivity than reported.

引用

页码：3292 / 3308

页数：18