Thrombocytopenia after vaccination: Case reports to the US Vaccine Adverse Event Reporting System, 1990-2008

被引：15

作者：

Woo, Emily Jane ^{[1
]}

Wise, Robert P. ^{[1
]}

Menschik, David ^{[1
]}

Shadomy, Sean V. ^{[2
]}

Iskander, John ^{[2
]}

Beeler, Judy ^{[1
]}

Varricchio, Frederick ^{[1
]}

Ball, Robert ^{[1
]}

机构：

[1] US FDA, CBER, OBE, Rockville, MD 20852 USA

[2] Ctr Dis Control & Prevent, Atlanta, GA USA

来源：

VACCINE | 2011年 / 29卷 / 06期

关键词：

Vaccine; Thrombocytopenia; Postmarketing safety; Adverse event; POSTLICENSURE SAFETY SURVEILLANCE; VARICELLA VACCINE; UNITED-STATES; MMR VACCINE; PURPURA; IMMUNIZATION; RUBELLA; VAERS; DRUG; ANTIBODIES;

D O I：

10.1016/j.vaccine.2010.11.051

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We reviewed thrombocytopenia (TP) reports to the US Vaccine Adverse Event Reporting System (VAERS). We examined TP patterns for differences in single versus multiple immunization reports, presence of a live viral vaccine, seriousness, age, and interval to symptom onset. We found 1510 reports of possible TP and after exclusions evaluated 1440 for possible causes. Most (1078; 75%) met the regulatory definition of a serious adverse event. TP was reported after inactivated and live viral vaccines. Platelet counts <10 x 10(9)/L were reported. Identified vaccines could be prioritized for hypothesis-testing studies. Published by Elsevier Ltd.

引用

页码：1319 / 1323

页数：5

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