Aberrant somatic hypermutation and expression of activation-induced cytidine deaminase mRNA in mediastinal large B-cell lymphoma

被引：27

作者：

Bödör, C

Bognár, A

Reiniger, L

Szepesi, A

Tóth, E

Kopper, L

Matolcsy, A

机构：

[1] Semmelweis Univ, Fac Med, Dept Pathol & Expt Canc Res 1, H-1085 Budapest, Hungary

[2] Hungarian Acad Sci, Natl Inst Oncol, Dept Mol Pathol, Budapest, Hungary

[3] Hungarian Acad Sci, Joint Res Org, Dept Mol Pathol, Budapest, Hungary

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2005年 / 129卷 / 03期

关键词：

aberrant somatic hypermutation; activation-induced cytidine deaminase; mediastinal large B-cell lymphoma;

D O I：

10.1111/j.1365-2141.2005.05454.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To determine the possible role of aberrant somatic hypermutation (ASHM) and activation-induced cytidine deaminase ( AID) expression in the pathogenesis of mediastinal large B-cell lymphoma ( MBL), the mutational status of genes affected by ASHM, including c-MYC, PAX- 5 and RhoH, was analysed, and the expression level of AID mRNA in tumour specimens from six patients with MBL was determined. Mutations in one or more genes and high expression of AID mRNA were detected in all the six cases of MBL. These results suggest that ASHM and AID expression may have a role in the pathogenesis of MBL.

引用

页码：373 / 376

页数：4

共 12 条

[1] Interleukin 4-induced gene 1 is activated in primary mediastinal large B-cell lymphoma [J].

Copie-Bergman, C ;

Boulland, ML ;

Dehoulle, C ;

Möller, P ;

Farcet, JP ;

Dyer, MJS ;

Haioun, C ;

Roméo, PH ;

Gaulard, P ;

Leroy, K .

BLOOD, 2003, 101 (07) :2756-2761

[2] Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma [J].

Gaidano, G ;

Pasqualucci, L ;

Capello, D ;

Berra, E ;

Deambrogi, C ;

Rossi, D ;

Larocca, LM ;

Gloghini, A ;

Carbone, A ;

Dalla-Favera, R .

BLOOD, 2003, 102 (05) :1833-1841

[3] Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas [J].

Greeve, J ;

Philipsen, A ;

Krause, K ;

Klapper, W ;

Heidom, K ;

Castle, BE ;

Janda, J ;

Marcu, KB ;

Parwaresch, R .

BLOOD, 2003, 101 (09) :3574-3580

[4]

JAFFE E, 2001, WHO PATHOLOGY GENETI, P175

[5] Primary diffuse large B-cell lymphomas of the central nervous system are targeted by aberrant somatic hypermutation [J].

Montesinos-Rongen, M ;

Van Roost, D ;

Schaller, C ;

Wiestler, OD ;

Deckert, M .

BLOOD, 2004, 103 (05) :1869-1875

[6] Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme [J].

Muramatsu, M ;

Kinoshita, K ;

Fagarasan, S ;

Yamada, S ;

Shinkai, Y ;

Honjo, T .

CELL, 2000, 102 (05) :553-563

[7] Constitutive expression of AID leads to tumorigenesis [J].

Okazaki, I ;

Hiai, H ;

Kakazu, N ;

Yamada, S ;

Muramatsu, M ;

Kinoshita, K ;

Honjo, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (09) :1173-1181

[8] Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas [J].

Pasqualucci, L ;

Neumeister, P ;

Goossens, T ;

Nanjangud, G ;

Chaganti, RSK ;

Küppers, R ;

Dalla-Favera, R .

NATURE, 2001, 412 (6844) :341-346

[9] Primary mediastinal B-cell lymphoma - High frequency of BCL-6 mutations and consistent expression of the transcription factors OCT-2, BOB.1, and PU.1 in the absence of immunoglobulins [J].

Pileri, SA ;

Gaidano, G ;

Zinzani, PL ;

Falini, B ;

Gaulard, P ;

Zucca, E ;

Pieri, F ;

Berra, E ;

Sabattini, E ;

Ascani, S ;

Piccioli, M ;

Johnson, PWM ;

Giardini, R ;

Pescarmona, E ;

Novero, D ;

Piccaluga, PP ;

Marafioti, T ;

Alonso, MA ;

Cavalli, F .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (01) :243-253

[10] Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma [J].

Rosenwald, A ;

Wright, G ;

Leroy, K ;

Yu, X ;

Gaulard, P ;

Gascoyne, RD ;

Chan, WC ;

Zhao, T ;

Haioun, C ;

Greiner, TC ;

Weisenburger, DD ;

Lynch, JC ;

Vose, J ;

Armitage, JO ;

Smeland, EB ;

Kvaloy, S ;

Holte, H ;

Delabie, J ;

Campo, E ;

Montserrat, E ;

Lopez-Guillermo, A ;

Ott, G ;

Muller-Hermelink, HK ;

Connors, JM ;

Braziel, R ;

Grogan, TM ;

Fisher, RI ;

Miller, TP ;

LeBlanc, M ;

Chiorazzi, M ;

Zhao, H ;

Yang, LM ;

Powell, J ;

Wilson, WH ;

Jaffe, ES ;

Simon, R ;

Klausner, RD ;

Staudt, LM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (06) :851-862

← 1 2 →