Trimeric chalchonoids from the total phenolic extract of Chinese dragon's blood (the red resin of Dracaena cochinchinensis)

被引：9
|
作者：
Pang, Dao-Ran [1 ]
Zou, Qiu-Yu [1 ]
Zhu, Zhi-Xiang [1 ]
Wang, Xin-Yu [1 ]
Pei, Yu-Jie [1 ]
Huo, Hui-Xia [1 ]
Zhao, Yun-Fang [1 ]
Tu, Peng-Fei [1 ]
Zheng, Jiao [1 ]
Li, Jun [1 ]
机构：
[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
来源：
FITOTERAPIA | 2021年 / 154卷
基金：
中国国家自然科学基金;
关键词：
Chinese dragon's blood; Dracaena cochinchinensis; Chalchonoid trimers; BV-2; microglial; ABSOLUTE-CONFIGURATION; FLAVONOID OLIGOMERS; MANSOINS;
D O I：
10.1016/j.fitote.2021.105029
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new chalchonoid trimers, named cochinchinenins N-Q (1-4), along with a pair of known enantiomers (5-6), were isolated from the total phenolic extract of Chinese dragon's blood (the red resin of Dracaena cochinchinensis). The planar structures of 1-4 were elucidated by extensive spectroscopic analysis including HRESIMS and 1D/2D NMR. The absolute configurations of new compounds were established by ECD data. Compound 1 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 value of 11.5 +/- 1.7 mu M.
引用
收藏
页数：6
相关论文
共 50 条
  • [41] Antibacterial Activity Against Ralstonia solanacearum of Phenolic Constituents Isolated from Dragon's Blood
    Wang, Hui
    Luo, Ying
    Dai, Haofu
    Mei, Wenli
    NATURAL PRODUCT COMMUNICATIONS, 2013, 8 (03) : 337 - 338
  • [42] Chinese Dragon's Blood EtOAc Extract Inhibits Liver Cancer Growth Through Downregulation of Smad3
    Chen, Xiaonan
    Zhao, Yanan
    Yang, Ailin
    Tian, Yingying
    Pang, Daoran
    Sun, Jing
    Tang, Leimengyuan
    Huang, Huiming
    Wang, Ying
    Zhao, Yunfang
    Tu, Pengfei
    Hu, Zhongdong
    Li, Jun
    FRONTIERS IN PHARMACOLOGY, 2020, 11
  • [43] Inhibition on acid-sensing ion channels and analgesic activities of flavonoids isolated from dragon's blood resin
    Wan, Ying
    Yu, Yi
    Pan, Xinxin
    Mo, Xiaoqiang
    Gong, Weifan
    Liu, Xiangming
    Chen, Su
    PHYTOTHERAPY RESEARCH, 2019, 33 (03) : 718 - 727
  • [44] Isolation and Characterization of Two Chalcone Derivatives with Anti-Hepatitis B Virus Activity from the Endemic Socotraen Dracaena cinnabari (Dragon's Blood Tree)
    Mothana, Ramzi A.
    Arbab, Ahmed H.
    ElGamal, Ali A.
    Parvez, Mohammad K.
    Al-Dosari, Mohammed S.
    MOLECULES, 2022, 27 (03):
  • [45] Natural potential therapeutic agents of neurodegenerative diseases from the traditional herbal medicine Chinese Dragon's Blood
    Li, Ning
    Ma, Zhongjun
    Li, Mujie
    Xing, Yachao
    Hou, Yue
    JOURNAL OF ETHNOPHARMACOLOGY, 2014, 152 (03) : 508 - 521
  • [46] Total phenolic content, antioxidant activity and tyrosinase inhibitor from marine red algae extract collected from Kupang, East Nusa Tenggara
    Nursid, M.
    Khatulistiani, T. S.
    Noviendri, D.
    Hapsari, F.
    Hardiyati, T.
    INTERNATIONAL CONFERENCE ON SUSTAINABLE AQUATIC RESOURCES, 2020, 493
  • [47] Antibacterial and Anti-biofilm Efficacy of Chinese Dragon's Blood Against Staphylococcus aureus Isolated From Infected Wounds
    Zheng, Xiangkuo
    Chen, Lijiang
    Zeng, Weiliang
    Liao, Wenli
    Wang, Zhongyong
    Tian, Xuebin
    Fang, Renchi
    Sun, Yao
    Zhou, Tieli
    FRONTIERS IN MICROBIOLOGY, 2021, 12
  • [48] Development and application of an UHPLC-MS method for comparative pharmacokinetic study of phenolic components from dragon's blood in rats under simulated microgravity environment
    Li, Yujuan
    Li, George Q.
    Li, Yongzhi
    Deng, Yulin
    Deng, Li
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2016, 121 : 91 - 98
  • [49] Chinese dragon's blood ethyl acetate extract suppresses gastric cancer progression through induction of apoptosis and autophagy mediated by activation of MAPK and downregulation of the mTOR-Beclin1 signalling cascade
    Ouyang, Lishan
    Li, Jiaqi
    Chen, Xiaonan
    Huang, Huiming
    Tian, Yingying
    Li, Xingxing
    Pang, Daoran
    Wei, Xuejiao
    Xie, Jinxin
    Wang, Longyan
    Liu, Dongxiao
    Tu, Pengfei
    Li, Jun
    Hu, Zhongdong
    PHYTOTHERAPY RESEARCH, 2023, 37 (02) : 689 - 701
  • [50] Single-step purification of dracorhodin from dragon's blood resin of Daemonorops draco using high-speed counter-current chromatography combined with pH modulation
    Shi, Jianmei
    Hu, Ruilin
    Lu, Yanbin
    Sun, Cuirong
    Wu, Tianxing
    JOURNAL OF SEPARATION SCIENCE, 2009, 32 (23-24) : 4040 - 4047
12345