Trimeric chalchonoids from the total phenolic extract of Chinese dragon's blood (the red resin of Dracaena cochinchinensis)

被引：9

作者：

Pang, Dao-Ran ^{[1
]}

Zou, Qiu-Yu ^{[1
]}

Zhu, Zhi-Xiang ^{[1
]}

Wang, Xin-Yu ^{[1
]}

Pei, Yu-Jie ^{[1
]}

Huo, Hui-Xia ^{[1
]}

Zhao, Yun-Fang ^{[1
]}

Tu, Peng-Fei ^{[1
]}

Zheng, Jiao ^{[1
]}

Li, Jun ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China

来源：

FITOTERAPIA | 2021年 / 154卷

基金：

中国国家自然科学基金;

关键词：

Chinese dragon's blood; Dracaena cochinchinensis; Chalchonoid trimers; BV-2; microglial; ABSOLUTE-CONFIGURATION; FLAVONOID OLIGOMERS; MANSOINS;

D O I：

10.1016/j.fitote.2021.105029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new chalchonoid trimers, named cochinchinenins N-Q (1-4), along with a pair of known enantiomers (5-6), were isolated from the total phenolic extract of Chinese dragon's blood (the red resin of Dracaena cochinchinensis). The planar structures of 1-4 were elucidated by extensive spectroscopic analysis including HRESIMS and 1D/2D NMR. The absolute configurations of new compounds were established by ECD data. Compound 1 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 value of 11.5 +/- 1.7 mu M.

引用

页数：6

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