Trimeric chalchonoids from the total phenolic extract of Chinese dragon's blood (the red resin of Dracaena cochinchinensis)

被引：9
|
作者：
Pang, Dao-Ran [1 ]
Zou, Qiu-Yu [1 ]
Zhu, Zhi-Xiang [1 ]
Wang, Xin-Yu [1 ]
Pei, Yu-Jie [1 ]
Huo, Hui-Xia [1 ]
Zhao, Yun-Fang [1 ]
Tu, Peng-Fei [1 ]
Zheng, Jiao [1 ]
Li, Jun [1 ]
机构：
[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
来源：
FITOTERAPIA | 2021年 / 154卷
基金：
中国国家自然科学基金;
关键词：
Chinese dragon's blood; Dracaena cochinchinensis; Chalchonoid trimers; BV-2; microglial; ABSOLUTE-CONFIGURATION; FLAVONOID OLIGOMERS; MANSOINS;
D O I：
10.1016/j.fitote.2021.105029
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new chalchonoid trimers, named cochinchinenins N-Q (1-4), along with a pair of known enantiomers (5-6), were isolated from the total phenolic extract of Chinese dragon's blood (the red resin of Dracaena cochinchinensis). The planar structures of 1-4 were elucidated by extensive spectroscopic analysis including HRESIMS and 1D/2D NMR. The absolute configurations of new compounds were established by ECD data. Compound 1 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 value of 11.5 +/- 1.7 mu M.
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页数：6
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