Development of a new building block for the synthesis of silicon-based drugs and odorants:: Alternative synthesis of the retinoid agonist disila-bexarotene

被引：28

作者：

Buettner, Matthias W. ^{[1
]}

Naetscher, Jennifer B. ^{[1
]}

Burschka, Christian ^{[1
]}

Tacke, Reinhold ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Anorgan Chem, D-97074 Wurzburg, Germany

来源：

ORGANOMETALLICS | 2007年 / 26卷 / 19期

关键词：

D O I：

10.1021/om700570f

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

With 4,4,5,5-tetramethyl-2-(3,5,5,8,8-pentamethyl-5,8-disila-5,6,7,8-tetrahydro-2-naphthyl)-1,3,2-dioxaborolane (5) a new building block for the synthesis of biologically active 5,8-disila-5,6 7.8-tetrahydronaphthalene derivatives has been made available. The high synthetic potential of 5 has been demonstrated b, v the development of a new synthesis of the retinoid agonist disila-bexarotene (1).

引用

页码：4835 / 4838

页数：4

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