Paralogous Sm22α (TAGLN) genes map to mouse chromosomes 1 and 9:: Further evidence for a paralogous relationship

被引：25

作者：

Stanier, P

Abu-Hayyeh, S

Murdoch, JN

Eddleston, J

Copp, AJ

机构：

[1] Queen Charlottes & Chelsea Hosp, Div Paediat Obstet & Gynaecol, Act Res Lab Fetal Dev, London W6 0XG, England

[2] UCL, Inst Child Hlth, Neural Dev Unit, London WC1 N1EH, England

来源：

GENOMICS | 1998年 / 51卷 / 01期

关键词：

D O I：

10.1006/geno.1998.5381

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

SM22 alpha (TAGLN) is one of the earliest markers of differentiated smooth muscle, being expressed exclusively in the smooth muscle cells of adult tissues and transiently in embryonic skeletal and cardiac tissues. We have identified and mapped the mouse Tagln gene and a closely related gene, Sm22 alpha homolog (Tagln2). The chromosomal localization for Tagln was identified by linkage analysis to distal mouse chromosome 9 between D9Mit154 and D9Mit330, closely linked to the anchor locus D9Nds10. The localization of Tagln2 was also determined and was found to map between Fcgr2 and D1Mit149 on distal mouse chromosome 1. This localization is homologous to a region of human 1q21-q25 to which an EST representing human TAGLN2 was previously mapped. The two regions, distal mouse chromosome 1 and proximal mouse chromosome 9, and the human regions with conserved synteny (1q21-q25 and 11q22-qter) are believed to be paralogous, reflecting either conserved remnants of duplicated chromosomes or segments of chromosomes during vertebrate evolution. (C) 1998 Academic Press.

引用

页码：144 / 147

页数：4

共 20 条

[1] CHARACTERIZATION OF THE GENE FOR MP20 - A DROSOPHILA MUSCLE PROTEIN THAT IS NOT FOUND IN ASYNCHRONOUS OSCILLATORY FLIGHT-MUSCLE [J].

AYMESOUTHGATE, A ;

LASKO, P ;

FRENCH, C ;

PARDUE, ML .

JOURNAL OF CELL BIOLOGY, 1989, 108 (02) :521-531

[2] TOWARDS HIGH-RESOLUTION MAPS OF THE MOUSE AND HUMAN GENOMES - A FACILITY FOR ORDERING MARKERS TO 0.1 CM RESOLUTION [J].

BREEN, M ;

DEAKIN, L ;

MACDONALD, B ;

MILLER, S ;

SIBSON, R ;

TARTTELIN, E ;

AVNER, P ;

BOURGADE, F ;

GUENET, JL ;

MONTAGUTELLI, X ;

POIRIER, C ;

SIMON, D ;

TAILOR, D ;

BISHOP, M ;

KELLY, M ;

RYSAVY, F ;

RASTAN, S ;

NORRIS, D ;

SHEPHERD, D ;

ABBOTT, C ;

PILZ, A ;

HODGE, S ;

JACKSON, I ;

BOYD, Y ;

BLAIR, H ;

MASLEN, G ;

TODD, JA ;

REED, PW ;

STOYE, J ;

ASHWORTH, A ;

MCCARTHY, L ;

COX, R ;

SCHALKWYK, L ;

LEHRACH, H ;

KLOSE, J ;

GANGADHARAN, U ;

BROWN, S .

HUMAN MOLECULAR GENETICS, 1994, 3 (04) :621-627

[3] Mouse chromosome 9 [J].

Imai, K .

MAMMALIAN GENOME, 1997, 7 (Suppl 1) :S159-S175

[4] Paralogy mapping: Identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci [J].

Katsanis, N ;

Fitzgibbon, J ;

Fisher, EMC .

GENOMICS, 1996, 35 (01) :101-108

[5] Mapping of the rat SM22 gene to Chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy [J].

Koike, G ;

Miano, JM ;

Vanvooren, P ;

Shiozawa, M ;

Szpirer, C ;

Jacob, HJ .

MAMMALIAN GENOME, 1998, 9 (01) :76-77

[6]

LEESMILLER JP, 1987, J BIOL CHEM, V262, P2988

[7] SM22 alpha, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis [J].

Li, L ;

Miano, JM ;

Cserjesi, P ;

Olsen, EN .

CIRCULATION RESEARCH, 1996, 78 (02) :188-195

[8]

LI L, 1996, J CELL BIOL, V132, P848

[9]

LI WH, 1982, ISOZYMES-CURR T BIOL, V6, P55

[10]

LI WH, 1991, FUNDAMENTALS GENETIC, P52

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