The Serum Metabolome of Moderate and Severe COVID-19 Patients Reflects Possible Liver Alterations Involving Carbon and Nitrogen Metabolism

被引：62

作者：

Caterino, Marianna ^{[1
,2
]}

Costanzo, Michele ^{[1
,2
]}

Fedele, Roberta ^{[1
]}

Cevenini, Armando ^{[1
,2
]}

Gelzo, Monica ^{[1
,2
]}

Di Minno, Alessandro ^{[1
,3
]}

Andolfo, Immacolata ^{[1
,2
]}

Capasso, Mario ^{[1
,2
]}

Russo, Roberta ^{[1
,2
]}

Annunziata, Anna ^{[4
]}

Calabrese, Cecilia ^{[5
]}

Fiorentino, Giuseppe ^{[4
]}

D'Abbraccio, Maurizio ^{[6
]}

Dell'Isola, Chiara ^{[6
]}

Fusco, Francesco Maria ^{[6
]}

Parrella, Roberto ^{[6
]}

Fabbrocini, Gabriella ^{[7
]}

Gentile, Ivan ^{[7
]}

Castaldo, Giuseppe ^{[1
,2
]}

Ruoppolo, Margherita ^{[1
,2
]}

机构：

[1] CEINGE Biotecnol Avanzate Scarl, I-80145 Naples, Italy

[2] Univ Napoli Federico II, Scuola Med & Chirurg, Dipartimento Med Mol & Biotecnol Med, I-80131 Naples, Italy

[3] Univ Napoli Federico II, Dipartimento Farm, I-80131 Naples, Italy

[4] Azienda Osped Specialist Colli Napoli, Fisiopatologia & Riabilitazione Resp 1 Utsir COVI, I-80137 Naples, Italy

[5] Univ Campania Luigi Vanvitelli, Dipartimento Sci Med Traslazionali, I-81100 Naples, Italy

[6] Azienda Osped Specialist Colli Napoli, COVID Unit, Dipartimento Malattie Infett Urgenze Infettivol, I-80137 Naples, Italy

[7] Univ Napoli Federico II, Dipartimento Med Clin & Chirurg, I-80131 Naples, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 17期

关键词：

COVID-19; SARS-CoV-2; coronavirus; metabolomics; mass spectrometry; serum cytokines; lactic acid; CAFFEINE-POTENTIATED CHEMOTHERAPY; LACTATE METABOLISM; CARCINOMA; HYPOXIA;

D O I：

10.3390/ijms22179548

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

COVID-19 is a global threat that has spread since the end of 2019, causing severe clinical sequelae and deaths, in the context of a world pandemic. The infection of the highly pathogenetic and infectious SARS-CoV-2 coronavirus has been proven to exert systemic effects impacting the metabolism. Yet, the metabolic pathways involved in the pathophysiology and progression of COVID-19 are still unclear. Here, we present the results of a mass spectrometry-based targeted metabolomic analysis on a cohort of 52 hospitalized COVID-19 patients, classified according to disease severity as mild, moderate, and severe. Our analysis defines a clear signature of COVID-19 that includes increased serum levels of lactic acid in all the forms of the disease. Pathway analysis revealed dysregulation of energy production and amino acid metabolism. Globally, the variations found in the serum metabolome of COVID-19 patients may reflect a more complex systemic perturbation induced by SARS-CoV-2, possibly affecting carbon and nitrogen liver metabolism.

引用

页数：18

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