Vitamin K-Dependent Proteins in Skeletal Development and Disease

被引：37

作者：

Stock, Michael ^{[1
,2
,3
]}

Schett, Georg ^{[1
,2
,3
]}

机构：

[1] Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med 3, D-91054 Erlangen, Germany

[2] Univ Klinikum Erlangen, D-91054 Erlangen, Germany

[3] Friedrich Alexander Univ Erlangen Nurnberg, Zentrum Immuntherapie, D-91054 Erlangen, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 17期

关键词：

vitamin K; vitamin K-dependent proteins; osteocalcin; matrix Gla protein; Ucma; GRP; MATRIX GLA-PROTEIN; GAMMA-CARBOXYGLUTAMIC ACID; BONE-MINERAL DENSITY; SERUM UNDERCARBOXYLATED OSTEOCALCIN; RECEPTOR TYROSINE KINASE; RICH PROTEIN; OSTEOBLAST DIFFERENTIATION; OSTEOARTHRITIC CARTILAGE; ORAL ANTICOAGULANTS; KNEE OSTEOARTHRITIS;

D O I：

10.3390/ijms22179328

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vitamin K and Vitamin K-dependent proteins (VKDPs) are best known for their pivotal role in blood coagulation. Of the 14 VKPDs identified in humans to date, 6 play also important roles in skeletal biology and disease. Thus, osteocalcin, also termed bone Gla-protein, is the most abundant non-collagenous protein in bone. Matrix Gla protein and Ucma/GRP on the other hand are highly abundant in cartilage. Furthermore, periostin, protein S, and growth arrest specific 6 protein (GAS 6) are expressed in skeletal tissues. The roles for these VKDPs are diverse but include the control of calcification and turnover of bone and cartilage. Vitamin K plays an important role in osteoporosis and serum osteocalcin levels are recognized as a promising marker for osteoporosis. On the other hand, matrix Gla protein and Ucma/GRP are associated with osteoarthritis. This review focuses on the roles of these three VKDPs, osteocalcin, matrix Gla protein and Ucma/GRP, in skeletal development and disease but will also summarize the roles the other skeletal VKDPs (periostin, protein S and GAS6) in skeletal biology.

引用

页数：16

共 114 条

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