Anti-infective Potential of Manzamine Alkaloids-A Review

被引：6

作者：

Ashok, Penta ^{[1
]}

Faheem ^{[1
]}

Kumar, Banoth K. ^{[1
]}

Chander, Subhash ^{[2
]}

Sekhar, Kondapalli Venkata Gowri Chandra ^{[3
]}

Sankaranarayanan, Murugesan ^{[1
]}

机构：

[1] Birla Inst Technol & Sci Pilani, Dept Pharm, Med Chem Res Lab, Pilani Campus, Pilani 333031, Rajasthan, India

[2] Amity Univ, Amity Inst Phytomed & Phytochem AIP&P, Sect 125, Noida 201313, Uttar Pradesh, India

[3] Birla Inst Technol & Sci Pilani, Dept Chem, Hyderabad Campus, Hyderabad 500078, Telangana, India

来源：

MEDICINAL CHEMISTRY | 2022年 / 18卷 / 06期

关键词：

Manzamine; carboline; malaria; leishmaniasis; tuberculosis; human immunodeficiency virus; bacteria; fungi; GLYCOGEN-SYNTHASE KINASE-3; INDONESIAN MARINE SPONGE; PLAUSIBLE BIOGENETIC PRECURSORS; ANTIMALARIAL ACTIVITY; NATURAL-PRODUCTS; IRCINAL-A; INHIBITORS; ANTIBACTERIAL; MYCOBACTERIA; KAULUAMINE;

D O I：

10.2174/1573406417666210803101740

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Background: From time immemorial, natural products have been used for the treatment of various diseases. Various natural products, their semisynthetic derivatives, and synthetic analogs have been explored for their anti-infective properties. One such group of natural compounds that has been widely explored is manzamine alkaloids. Manzamine alkaloids are complex natural compounds consisting of a beta-carboline nucleus attached to a pentacyclic ring system; they were first isolated from a marine sponge during the 1980s. Objective: This review aims to provide a critical overview on the anti-infective potential of manzamine alkaloids. Methods: A comprehensive and exhaustive review of the literature on manzamine alkaloids, and their isolation, anti-infective properties, and mechanism of action, is presented. Results: Various manzamine alkaloids have been isolated and have been found to exhibit potent anti-infective activities like antibacterial, antimalarial, antiviral, antifungal, antileishmanial, among others. These manzamine alkaloids exhibit their anti-infective activity by inhibiting targets like GSK-3 beta, MtSK. Conclusion: This present review along with structure-activity relationship study of manzamine alkaloids for their anti-infective activity will be useful for further development of semisynthetic manzamine analogs as potent anti-infective agents with better therapeutic potential and reduced toxicity.

引用

页码：629 / 654

页数：26

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