Co(II) PCP Pincer Complexes as Catalysts for the Alkylation of Aromatic Amines with Primary Alcohols

被引：174

作者：

Mastalir, Matthias ^{[1
]}

Tomsu, Gerald ^{[1
]}

Pittenauer, Ernst ^{[2
]}

Allmaier, Guenter ^{[2
]}

Kirchner, Karl ^{[1
]}

机构：

[1] Vienna Univ Technol, Inst Appl Synthet Chem, Getreidemarkt 9-163-AC, A-1060 Vienna, Austria

[2] Vienna Univ Technol, Inst Chem Technol & Analyt, Getreidemarkt 9-163-AC, A-1060 Vienna, Austria

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 14期

基金：

奥地利科学基金会;

关键词：

BORROWING HYDROGEN METHODOLOGY; MILD REACTION CONDITIONS; N-ALKYLATION; SECONDARY ALCOHOLS; ACCEPTORLESS DEHYDROGENATION; (HETERO)AROMATIC AMINES; SELECTIVE ALKYLATION; EFFICIENT CATALYSTS; TERTIARY-AMINES; IRIDIUM COMPLEX;

D O I：

10.1021/acs.orglett.6b01647

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient alkylations of amines by alcohols catalyzed by well-defined Co(II) complexes are described that are stabilized by a PCP ligand (N,N '-bis-(diisopropylphosphino)-N,N '-dimethyl-1,3-diaminobenzene) based on the 1,3-diaminobenzene scaffold. This reaction is an environmentally benign process implementing inexpensive, earth-abundant nonprecious metal catalysts and is based on the acceptorless alcohol dehydrogenation concept. A range of primary alcohols and aromatic amines were efficiently converted into mono-N-alkylated amines in good to excellent isolated yields.

引用

页码：3462 / 3465

页数：4

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