Co(II) PCP Pincer Complexes as Catalysts for the Alkylation of Aromatic Amines with Primary Alcohols

被引：172
作者：
Mastalir, Matthias [1 ]
Tomsu, Gerald [1 ]
Pittenauer, Ernst [2 ]
Allmaier, Guenter [2 ]
Kirchner, Karl [1 ]
机构：
[1] Vienna Univ Technol, Inst Appl Synthet Chem, Getreidemarkt 9-163-AC, A-1060 Vienna, Austria
[2] Vienna Univ Technol, Inst Chem Technol & Analyt, Getreidemarkt 9-163-AC, A-1060 Vienna, Austria
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 14期
基金：
奥地利科学基金会;
关键词：
BORROWING HYDROGEN METHODOLOGY; MILD REACTION CONDITIONS; N-ALKYLATION; SECONDARY ALCOHOLS; ACCEPTORLESS DEHYDROGENATION; (HETERO)AROMATIC AMINES; SELECTIVE ALKYLATION; EFFICIENT CATALYSTS; TERTIARY-AMINES; IRIDIUM COMPLEX;
D O I：
10.1021/acs.orglett.6b01647
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Efficient alkylations of amines by alcohols catalyzed by well-defined Co(II) complexes are described that are stabilized by a PCP ligand (N,N '-bis-(diisopropylphosphino)-N,N '-dimethyl-1,3-diaminobenzene) based on the 1,3-diaminobenzene scaffold. This reaction is an environmentally benign process implementing inexpensive, earth-abundant nonprecious metal catalysts and is based on the acceptorless alcohol dehydrogenation concept. A range of primary alcohols and aromatic amines were efficiently converted into mono-N-alkylated amines in good to excellent isolated yields.
引用
收藏
页码：3462 / 3465
页数：4
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