What happens to bacterial pathogens in vivo?

被引:73
作者
Smith, H [1 ]
机构
[1] Univ Birmingham, Sch Med, Birmingham B1S 2TT, W Midlands, England
关键词
D O I
10.1016/S0966-842X(98)01250-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Most of our current knowledge about the molecular determinants of bacterial pathogenicity comes from studies with cultures in vitro. However, interest is increasing in bacterial behaviour in the complex and ever-changing environment of the infected host. New methods are revealing how bacteria behave in their hosts, providing many surprises and indicating how much of the subject remains unexplored.
引用
收藏
页码:239 / 243
页数:5
相关论文
共 44 条
  • [1] Co-ordinate regulation of Salmonella typhimurium invasion genes by environmental and regulatory factors is mediated by control of hilA expression
    Bajaj, V
    Lucas, RL
    Hwang, C
    Lee, CA
    [J]. MOLECULAR MICROBIOLOGY, 1996, 22 (04) : 703 - 714
  • [2] BUSBY SJW, 1998, NATO ASI SERIES, V103
  • [3] Use of recombinase gene fusions to identify Vibrio cholerae genes induced during infection
    Camilli, A
    Mekalanos, JJ
    [J]. MOLECULAR MICROBIOLOGY, 1995, 18 (04) : 671 - 683
  • [4] USE OF GENETIC-RECOMBINATION AS A REPORTER OF GENE-EXPRESSION
    CAMILLI, A
    BEATTIE, DT
    MEKALANOS, JJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (07) : 2634 - 2638
  • [5] Salmonella spp are cytotoxic for cultured macrophages
    Chen, LM
    Kaniga, K
    Galan, JE
    [J]. MOLECULAR MICROBIOLOGY, 1996, 21 (05) : 1101 - 1115
  • [6] Invasion of murine intestinal M cells by Salmonella typhimurium inv mutants severely deficient for invasion of cultured cells
    Clark, MA
    Reed, KA
    Lodge, J
    Stephen, J
    Hirst, BH
    Jepson, MA
    [J]. INFECTION AND IMMUNITY, 1996, 64 (10) : 4363 - 4368
  • [7] In search of tuberculosis virulence genes
    Collins, DM
    [J]. TRENDS IN MICROBIOLOGY, 1996, 4 (11) : 426 - 430
  • [8] Photonic detection of bacterial pathogens in living hosts
    Contag, CH
    Contag, PR
    Mullins, JI
    Spilman, SD
    Stevenson, DK
    Benaron, DA
    [J]. MOLECULAR MICROBIOLOGY, 1995, 18 (04) : 593 - 603
  • [9] The Yersinia Yop virulon: A bacterial system for subverting eukaryotic cells
    Cornelis, GR
    WolfWatz, H
    [J]. MOLECULAR MICROBIOLOGY, 1997, 23 (05) : 861 - 867
  • [10] Comparative analysis of the virulence control systems of Bordetella pertussis and Bordetella bronchiseptica
    deTejada, GM
    Miller, JF
    Cotter, PA
    [J]. MOLECULAR MICROBIOLOGY, 1996, 22 (05) : 895 - 908