Resveratrol inhibits the growth of gastric cancer via the Wnt/-catenin pathway

被引：40

作者：

Dai, Hui ^{[1
]}

Deng, Hou-Bo ^{[2
]}

Wang, Ya-Hong ^{[2
]}

Guo, Jia-Juan ^{[3
]}

机构：

[1] Changchun Univ Tradit Chinese Med, Affiliated Hosp, Dept Tumor & Blood Dis, Changchun 130021, Jilin, Peoples R China

[2] Changchun Univ Tradit Chinese Med, Affiliated Hosp, Dept Liver Spleen & Stomach Dis, Changchun 130021, Jilin, Peoples R China

[3] Changchun Univ Tradit Chinese Med, Affiliated Hosp, Dept Cardiovasc Dis, 1478 Gongnong Rd, Changchun 130021, Jilin, Peoples R China

来源：

ONCOLOGY LETTERS | 2018年 / 16卷 / 02期

关键词：

resveratrol; gastric cancer cells; Wnt; -catenin signaling pathway; BETA-CATENIN; E-CADHERIN; EXPRESSION; THERAPY; CARCINOMA;

D O I：

10.3892/ol.2018.8772

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The inhibitory effect of resveratrol on the growth of gastric cancer cells through downregulation of the Wnt/-catenin signaling pathway were studied. First we determined the effective concentration of resveratrol on the growth and proliferation of MGC-803 gastric cancer cells. Methylthiazolyl tetrazolium assay showed that resveratrol significantly inhibited the proliferation of MGC-803 cells in a dose-dependent manner. Resveratrol induced apoptotic morphological changes in MGC-803 cells. Reverse transcription-polymerase chain reaction and western blot analysis showed that resveratrol downregulated the expression of three important components of the Wnt signaling pathway, -catenin, c-myc, and cyclin D1, at the mRNA and protein levels. Overall, resveratrol inhibits the growth of MGC-803 cells by inhibiting the Wnt signaling pathway. This study provides a new idea and direction for the antitumor mechanism of resveratrol.

引用

页码：1579 / 1583

页数：5

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