Role of Hippo-YAP1/TAZ pathway and its crosstalk in cardiac biology

被引：24

作者：

Chen, Xiaoqing ^{[1
,2
]}

Yuan, Wenchang ^{[3
]}

Li, Yilang ^{[1
,2
]}

Luo, Jiandong ^{[1
,2
]}

Hou, Ning ^{[1
,2
]}

机构：

[1] Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Target & Clin Pharmacol, Guangzhou 511436, Peoples R China

[2] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Peoples R China

[3] Guangzhou Med Univ, KingMed Sch Lab Med, Guangzhou 511436, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2020年 / 16卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Hippo pathway; Wnt signaling; BMP signaling; GPCR signaling; cardiac biology; HIPPO SIGNALING PATHWAY; PROTEIN-COUPLED RECEPTOR; WNT/BETA-CATENIN; CARDIOMYOCYTE PROLIFERATION; ENDOTHELIAL-CELLS; TUMOR-SUPPRESSOR; BREAST-CANCER; SIZE CONTROL; YAP; PHOSPHORYLATION;

D O I：

10.7150/ijbs.47142

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Hippo pathway undertakes a pivotal role in organ size control and the process of physiology and pathology in tissue. Its downstream effectors YAP1 and TAZ receive upstream stimuli and exert transcription activity to produce biological output. Studies have demonstrated that the Hippo pathway contributes to maintenance of cardiac homeostasis and occurrence of cardiac disease. And these cardiac biological events are affected by crosstalk among Hippo-YAP1/TAZ, Wnt/beta-catenin, Bone morphogenetic protein (BMP) and G-protein-coupled receptor (GPCR) signaling, which provides new insights into the Hippo pathway in heart. This review delineates the interaction among Hippo, Wnt, BMP and GPCR pathways and discusses the effects of these pathways in cardiac biology.

引用

页码：2454 / 2463

页数：10

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