The in vivo fate and targeting engineering of crossover vesicle-based gene delivery system

被引：46
作者：
Jiang, Xin-Chi [1 ,2 ]
Zhang, Tianyuan [1 ,2 ]
Gao, Jian-Qing [1 ,2 ,3 ,4 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
[2] Zhejiang Univ, Li Dak Sum & Yip Yio Chin Ctr Stem Cell & Regenera, Hangzhou 310058, Zhejiang, Peoples R China
[3] Zhejiang Univ, Hangzhou Inst Innovat Med, Hangzhou 310058, Zhejiang, Peoples R China
[4] Zhejiang Univ, Affiliated Hosp 2, Dept Pharm, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2022年 / 187卷
基金：
中国博士后科学基金;
关键词：
Exosomes; Biomimetic vesicles; Targeting; Gene delivery system; CRISPR; Cas9; EXOSOME-MIMETIC NANOVESICLES; MESENCHYMAL STEM-CELLS; MILK-DERIVED EXOSOMES; EXTRACELLULAR VESICLES; DRUG-DELIVERY; BLOOD EXOSOMES; MESSENGER-RNA; B16BL6-DERIVED EXOSOMES; QUANTITATIVE-ANALYSIS; MEDIATED ENDOCYTOSIS;
D O I：
10.1016/j.addr.2022.114324
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Exosomes and biomimetic vesicles are widely used for gene delivery because of their excellent gene loading capacity and stability and their natural targeting delivery potential. These vesicles take advantages of both cell-based bioactive delivery system and synthetical lipid-derived nanovectors to form crossover characteristics. To further optimize the specific targeting properties of crossover vesicles, studies of their in vivo fate and various engineering approaches including nanobiotechnology are required. This review describes the preparation process of exosomes and biomimetic vesicles, and summarizes the mechanism of loading and delivery of nucleic acids or gene editing systems. We provide a comprehensive overview of the techniques employed for preparing the targeting crossover vesicles based on their cellular uptake and targeting mechanism. To delineate the future prospects of crossover vesicle gene delivery systems, various challenges and clinical applications of vesicles have also been discussed. (c) 2022 Elsevier B.V. All rights reserved.
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页数：24
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