The role of p38 MAP kinase in TGF-β1-induced signal transduction in human neutrophils

被引：103

作者：

Hannigan, M ^{[1
]}

Zhan, LJ ^{[1
]}

Ai, YX ^{[1
]}

Huang, CK ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Pathol, Farmington, CT 06030 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 246卷 / 01期

关键词：

D O I：

10.1006/bbrc.1998.8570

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transforming growth factor-beta 1 (TGF-beta 1) is the strongest chemoattractant yet described for human neutrophils. It activates neither phospholipase C nor phospholipase D. It does not induce rises in intracellular calcium, degranulation, or superoxide production. The signaling pathways utilized by TGF-beta 1 are largely unknown. This report demonstrates that TGF-beta 1 activates p38 MAP kinase. The kinase inhibitor SB203580 blocks the chemotactic responses as well as actin polymerization induced by TGF-beta 1. Potential cellular targets of the p38 MAP kinase pathway which could mediate these function are discussed. (C) 1998 Academic Press.

引用

页码：55 / 58

页数：4

共 21 条

[1] IDENTIFICATION OF NOVEL PHOSPHORYLATION SITES REQUIRED FOR ACTIVATION OF MAPKAP KINASE-2 [J].

BENLEVY, R ;

LEIGHTON, IA ;

DOZA, YN ;

ATTWOOD, P ;

MORRICE, N ;

MARSHALL, CJ ;

COHEN, P .

EMBO JOURNAL, 1995, 14 (23) :5920-5930

[2] The search for physiological substrates of MAP and SAP kinases in mammalian cells [J].

Cohen, P .

TRENDS IN CELL BIOLOGY, 1997, 7 (09) :353-361

[3] SB-203580 IS A SPECIFIC INHIBITOR OF A MAP KINASE HOMOLOG WHICH IS STIMULATED BY CELLULAR STRESSES AND INTERLEUKIN-1 [J].

CUENDA, A ;

ROUSE, J ;

DOZA, YN ;

MEIER, R ;

COHEN, P ;

GALLAGHER, TF ;

YOUNG, PR ;

LEE, JC .

FEBS LETTERS, 1995, 364 (02) :229-233

[4]

HAINES K, J IMMUNOL, V151, P1491

[5]

HOUT J, 1995, EUR J BIOCHEM, V227, P416

[6] LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils [J].

Huang, CK ;

Zhan, LJ ;

Ai, YX ;

Jongstra, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (01) :17-19

[7] Roles of phospholipase C beta 2 in chemoattractant-elicited responses [J].

Jiang, HP ;

Kuang, YN ;

Wu, YP ;

Xie, W ;

Simon, MI ;

Wu, DQ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (15) :7971-7975

[8] Identification of MAPKAPK homolog (MAPKAPK-4) as a myosin II regulatory light-chain kinase in sea urchin egg extracts [J].

Komatsu, S ;

Murai, N ;

Totsukawa, G ;

Abe, M ;

Akasaka, K ;

Shimada, H ;

Hosoya, H .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1997, 343 (01) :55-62

[9] Chemotactic peptide N-formyl-Met-Leu-Phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils [J].

Krump, E ;

Sanghera, JS ;

Pelech, SL ;

Furuya, W ;

Grinstein, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (02) :937-944

[10] Sounding the alarm: Protein kinase cascades activated by stress and inflammation [J].

Kyriakis, JM ;

Avruch, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (40) :24313-24316

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