The role of p38 MAP kinase in TGF-β1-induced signal transduction in human neutrophils

被引：102
|
作者：
Hannigan, M [1 ]
Zhan, LJ [1 ]
Ai, YX [1 ]
Huang, CK [1 ]
机构：
[1] Univ Connecticut, Ctr Hlth, Dept Pathol, Farmington, CT 06030 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 246卷 / 01期
关键词：
D O I：
10.1006/bbrc.1998.8570
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transforming growth factor-beta 1 (TGF-beta 1) is the strongest chemoattractant yet described for human neutrophils. It activates neither phospholipase C nor phospholipase D. It does not induce rises in intracellular calcium, degranulation, or superoxide production. The signaling pathways utilized by TGF-beta 1 are largely unknown. This report demonstrates that TGF-beta 1 activates p38 MAP kinase. The kinase inhibitor SB203580 blocks the chemotactic responses as well as actin polymerization induced by TGF-beta 1. Potential cellular targets of the p38 MAP kinase pathway which could mediate these function are discussed. (C) 1998 Academic Press.
引用
收藏
页码：55 / 58
页数：4
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