Nitrous oxide reverses the increase in striatal dopamine release produced by N-methyl-D-aspartate infusion in the substantia nigra pars compacta in rats

被引：19

作者：

Balon, N

Dupenloup, L

Blanc, F

Weiss, M

Rostain, JC

机构：

[1] IFR Jean Roche, Fac Med Nord, IMNSSA, Lab Physiopathol & Act Therapeut Gaz Press, F-13916 Marseille 20, France

[2] Univ Mediterranee, F-13916 Marseille 20, France

来源：

NEUROSCIENCE LETTERS | 2003年 / 343卷 / 02期

关键词：

basal ganglia; narcosis; rat; voltammetry;

D O I：

10.1016/S0304-3940(03)00340-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bilateral administration of NMDA (5 X 10(-10) mol) in the substantia nigra pars compacta increases the striatal dopamine (DA) release. However, this enhancing effect of NMDA was suppressed by nitrous oxide exposure at 0.1 MPa, which induced per se a decrease of the DA release. These results show that nitrous oxide exerts a reversal effect on the increase in striatal DA release produced by NMDA receptor activation in the substantia nigra pars compacta. This observation may be related to the fact that nitrous oxide is thought to produce its effects by acting as an NMDA receptor antagonist. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：147 / 149

页数：3

共 17 条

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