Flexible metathesis-based approaches to highly functionalised furans and pyrroles

被引：44

作者：

Donohoe, Timothy J. ^{[1
]}

Kershaw, Neil M. ^{[1
]}

Orr, Allan J. ^{[1
]}

Wheelhouse , Katherine M. P. ^{[1
]}

Fishlock, Lisa P. ^{[1
]}

Lacy, Adam R. ^{[1
]}

Bingham, Matilda ^{[2
]}

Procopiou, Panayiotis A. ^{[3
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

[2] Organon Res Labs Ltd, Dept Med Chem, Newhouse ML1 5SH, Lanark, Scotland

[3] GlaxoSmithKline Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON | 2008年 / 64卷 / 05期

基金：

英国工程与自然科学研究理事会;

关键词：

ring-closing metathesis; furan; pyrrole; arenes; catalysis;

D O I：

10.1016/j.tet.2007.09.087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A range of differentially functionalised furans and pyrroles have been synthesised in short order by the judicious use of a ring-closing metathesis/aromatisation strategy. Two contrasting approaches are described exploiting a palladium-catalysed union of allylic alcohols and sulfonamides in one case, and a titanium mediated methylenation of homoallylic esters in another. A number of groups that are difficult to install via traditional methods were incorporated successfully. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：809 / 820

页数：12

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