Temporal response of three-dimensional biological cells to high-frequency optical jumping tweezers

We analyzed the temporal responses of biological cells in the jumping optical tweezers for tugging, wiggling, and stretching the cells in the time-sharing regime with the finite-element method. We showed that the jumping of local stress and local strain is independently omnipresent on the recovery time of the viscoelastic material and the jumping frequency of the load. We demonstrated that the elongation of a three-dimensional (3-D) viscoelastic object under a jumping load cannot be evaluated using the one-dimensional spring-dashpot material model without considering its 3-D structure. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)