Diagnostic implications of uric acid in electroanalytical measurements

被引:36
作者
Dutt, JSN
Cardosi, MF
Livingstone, C
Davis, J [1 ]
机构
[1] Nottingham Trent Univ, Sch Biomed & Nat Sci, Nottingham NG11 8NS, England
[2] LifeScan Scotland, Inverness IV2 3ED, Scotland
[3] Royal Surrey Cty Hosp, NHS Trust, Guildford GU2 7XX, Surrey, England
关键词
uric acid; analysis; electroanalysis; diabetes; biosensors;
D O I
10.1002/elan.200403258
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Urate has a long history in clinical analysis and has served as an important diagnostic in a number of contexts. The increasing interest in metabolic syndrome has led to urate being used in combination with a number of other biomarkers in the assessment of cardiovascular risk. The traditional view of urate as principally an interferent in electrochemical measurement is now gradually being replaced with the realization that its measurement could serve as an invaluable secondary (if not primary) marker when monitoring conditions such as diabetes and heart disease. Rather than attempting to wholly exclude urate electrochemistry, many strategies are being developed that can integrate the urate signal within the device architecture such that a range of biomarkers can be sequentially assessed. The present review has sought to rationalize the clinical importance that urate measurements could hold in future diagnostic applications - particularly within near patient testing contexts. The technologies harnessed for its detection and also those previously employed for its removal are reviewed with the aim of highlighting how the seemingly contrasting approaches are evolving to aid the development of new sensing devices for clinical analysis.
引用
收藏
页码:1233 / 1243
页数:11
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