N-heterocyclic carbene-catalyzed amidation of unactivated esters with amino alcohols

被引：271
作者：
Movassaghi, M [1 ]
Schmidt, MA [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 12期
关键词：
D O I：
10.1021/ol050773y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] A catalytic amidation of unactivated esters with amino alcohols is described. A series of solution studies in addition to the first X-ray structure of a carbene-alcohol complex support a carbene-base nucleophile activation mechanism.
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页码：2453 / 2456
页数：4
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