Cytotoxic phenolic glycosides from the seeds of Senna tora

被引：4
作者：
Hanh, Tran Thi Hong [1 ]
Anh, Le Ngoc [1 ]
Trung, Nguyen Quang [2 ]
Quang, Tran Hong [1 ]
Anh, Do Hoang [1 ]
Cuong, Nguyen Xuan [1 ]
Nam, Nguyen Hoai [1 ]
Minh, Chau Van [1 ]
机构：
[1] Vietnam Acad Sci & Technol, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam
[2] VAST, Ctr Res & Technol Transfer, 18 Hoang Quoc Viet, Hanoi, Vietnam
来源：
PHYTOCHEMISTRY LETTERS | 2021年 / 45卷
关键词：
Senna tora; Cassia tora; Leguminosae; Phenolic glycoside; Cytotoxicity; RHUBARB RHEI RHIZOMA; INHIBITORY-ACTIVITY; CASSIA-TORA; ANTHRAQUINONES; CONSTITUENTS; DERIVATIVES;
D O I：
10.1016/j.phytol.2021.08.020
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Phytochemical investigations of Senna tora seeds led to the isolation of fourteen phenolic glycosides, including three new compounds, namely, sennatorosides A-C (1-3). The chemical structures of the isolated compounds were confirmed by a detailed analysis of the 1D and 2D NMR, HR-ESI-QTOF mass, and ECD spectra. Among the isolated compounds, 1-[(1-(<beta>-D-glucopyranosyl)oxy-8-hydroxy-methoxynaphthalen)-6-yl]propan-2-one (11) exhibited strong cytotoxic activity against three tested cancer cell lines, SK-LU-1 (lung cancer), HepG2 (hepatoma cancer), and MCF-7 (breast cancer), with IC50 values of 8.05 +/- 0.28, 9.52 +/- 1.20, and 8.54 +/- 0.85 mu M, respectively, whereas compounds 1-4, 6-9, 12, and 14 revealed moderated or weak cytotoxicity, with IC50 values ranging from 44.59 +/- 5.03-98.24 +/- 2.45 mu M.
引用
收藏
页码：190 / 194
页数：5
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